HitPredict

Interactor 1: TOLIP (Q9H0E2)
Toll-interacting protein
Gene: TOLLIP

Interactor 2: IL1AP (Q9NPH3)
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Gene: IL1RAP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	10854325, 13679373
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0006954 - inflammatory response GO:0045087 - innate immune response GO:0070498 - interleukin-1-mediated signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 274 Hs			1 570
+	Mm
		1143082 TOLIP_MOUSE (1-273): 2.66e-165: 460: 93.04		IL1AP_MOUSE (1-570): 1.31e-120: 369: 89.12
+	Rn
		58596 TOLIP_RAT (1-273): 9.9e-166: 461: 93.41		IL1AP_RAT (1-570): 3.65e-119: 365: 88.95
+	Hs
		540401 TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00		IL1R1_HUMAN (67-566): 2.25e-77: 256: 22.39
+	Mm
		528288 TOLIP_MOUSE (1-273): 2.66e-165: 460: 93.04		IL1R1_MOUSE (12-569): 8.3e-82: 268: 22.45
+	Rn
		58589 TOLIP_RAT (1-273): 9.9e-166: 461: 93.41		Q05KR0_RAT (67-569): 3.61e-80: 264: 23.99
+	Hs
		1327575 TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00		ILRL2_HUMAN (3-546): 2.45e-66: 227: 23.23
+	Hs
		1327620 TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		237519 TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00		TLR2_HUMAN (325-546): 1.51e-33: 138: 21.46
+	Hs
		120175 TOLIP_HUMAN (1-274): 6.84e-178: 492: 100.00		TLR4_HUMAN (405-570): 9.13e-23: 104: 23.39