Protein: IMA4
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)

Gene: IMA4, KPNA3
Organism: Homo sapiens
Interactions: 204
UniProt ID: O00505

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

131527

NUP50
Nuclear pore complex protein Nup50

5

20

High-throughput

0.932

High

131437

IMB1
Importin subunit beta-1

4

20

Small-scale

0.906

High

131376

RCC1
Regulator of chromosome condensation

4

2

Small-scale

0.899

High

131338

IMA3
Importin subunit alpha-3

2

7

High-throughput

0.789

High

131480

ESR2
Estrogen receptor beta

2

9

High-throughput

0.783

High

131362

ESR1
Estrogen receptor

2

9

High-throughput

0.737

High

131369

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

4

6

High-throughput

0.711

High

131436

KIF22
Kinesin-like protein KIF22

4

3

High-throughput

0.704

High

131414

RAN
GTP-binding nuclear protein Ran

1

5

High-throughput

0.691

High

131517

DDX21
Nucleolar RNA helicase 2

3

4

High-throughput

0.683

High

131407

NCBP2
Nuclear cap-binding protein subunit 2

4

5

High-throughput

0.678

High

131521

MAT2B
Methionine adenosyltransferase 2 subunit beta

3

2

High-throughput

0.675

High

131406

MECP2
Methyl-CpG-binding protein 2

3

7

High-throughput

0.675

High

131503

IER2
Immediate early response gene 2 protein

3

1

High-throughput

0.667

High

131422

NCBP1
Nuclear cap-binding protein subunit 1

3

5

High-throughput

0.662

High

131377

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

3

1

High-throughput

0.654

High

131439

BRD3
Bromodomain-containing protein 3

3

11

High-throughput

0.653

High

131533

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

1

High-throughput

0.640

High

131449

LARP7
La-related protein 7

3

7

Small-scale

0.633

High

131430

MTA1
Metastasis-associated protein MTA1

2

9

High-throughput

0.631

High

131412

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

4

High-throughput

0.628

High

131417

HSF1
Heat shock factor protein 1

2

4

High-throughput

0.628

High

131490

P121A
Nuclear envelope pore membrane protein POM 121

2

16

High-throughput

0.628

High

131368

NPM
Nucleophosmin

2

4

Small-scale

0.619

High

131421

RBBP4
Histone-binding protein RBBP4

2

10

Small-scale

0.619

High

131341

XPO1
Exportin-1

1

13

Small-scale

0.618

High

131499

CIC
Protein capicua homolog

1

7

High-throughput

0.618

High

131391

COIL
Coilin

2

2

High-throughput

0.614

High

131370

PARP1
Poly [ADP-ribose] polymerase 1

2

4

High-throughput

0.611

High

131420

CTSL2
CTD small phosphatase-like protein 2

2

4

Small-scale

0.611

High

131433

CUL3
Cullin-3

2

13

High-throughput

0.611

High

131466

F90A1
Protein FAM90A1

3

2

High-throughput

0.607

High

131389

ZNF76
Zinc finger protein 76

2

11

High-throughput

0.606

High

131395

RAD52
DNA repair protein RAD52 homolog

2

1

High-throughput

0.606

High

131398

MK09
Mitogen-activated protein kinase 9

2

3

High-throughput

0.606

High

131429

GRB10
Growth factor receptor-bound protein 10

2

2

High-throughput

0.606

High

131459

ZCH12
Zinc finger CCHC domain-containing protein 12

2

1

High-throughput

0.606

High

131463

ATOSB
Atos homolog protein B

2

1

High-throughput

0.606

High

131470

LMBL4
Lethal(3)malignant brain tumor-like protein 4

2

1

High-throughput

0.606

High

131483

KAT5
Histone acetyltransferase KAT5

2

7

High-throughput

0.606

High

131489

ZN764
Zinc finger protein 764

2

9

High-throughput

0.606

High

131493

TNIP3
TNFAIP3-interacting protein 3

2

1

High-throughput

0.606

High

131495

HEXI2
Protein HEXIM2

2

1

High-throughput

0.606

High

131504

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

5

High-throughput

0.606

High

131515

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

7

High-throughput

0.606

High

131397

CBX5
Chromobox protein homolog 5

2

16

Small-scale

0.601

High

131416

CBX1
Chromobox protein homolog 1

2

16

Small-scale

0.601

High

131360

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

12

High-throughput

0.586

High

131351

BRD4
Bromodomain-containing protein 4

2

13

High-throughput

0.584

High

131390

BRCA1
Breast cancer type 1 susceptibility protein

2

6

High-throughput

0.584

High

131419

TF65
Transcription factor p65

2

9

High-throughput

0.584

High

131431

SQSTM
Sequestosome-1

2

3

High-throughput

0.584

High

131462

MEPCE
7SK snRNA methylphosphate capping enzyme

2

6

High-throughput

0.584

High

131448

UVSSA
UV-stimulated scaffold protein A

2

0

High-throughput

0.580

High

131474

BAHD1
Bromo adjacent homology domain-containing 1 protein

2

0

High-throughput

0.580

High

131346

ZBT24
Zinc finger and BTB domain-containing protein 24

1

8

High-throughput

0.573

High

131361

FRIL
Ferritin light chain

1

5

High-throughput

0.573

High

131496

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

1

High-throughput

0.573

High

131468

SLX4
Structure-specific endonuclease subunit SLX4

2

9

High-throughput

0.571

High

131394

HD
Huntingtin

2

0

High-throughput

0.571

High

131456

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.553

High

131450

NCBP3
Nuclear cap-binding protein subunit 3

2

2

High-throughput

0.552

High

131494

SMIP9
Protein SPMIP9

1

0

High-throughput

0.549

High

131366

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

131373

MYOD1
Myoblast determination protein 1

1

3

High-throughput

0.541

High

131401

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

131445

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

High-throughput

0.541

High

131482

GATA6
Transcription factor GATA-6

1

3

High-throughput

0.541

High

131532

FA50B
Protein FAM50B

1

1

High-throughput

0.541

High

131337

NOP56
Nucleolar protein 56

1

13

High-throughput

0.536

High

131339

CUX2
Homeobox protein cut-like 2

1

2

High-throughput

0.536

High

131344

PPM1D
Protein phosphatase 1D

1

2

High-throughput

0.536

High

131347

MED14
Mediator of RNA polymerase II transcription subunit 14

1

3

High-throughput

0.536

High

131350

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

6

High-throughput

0.536

High

131352

NPM3
Nucleoplasmin-3

1

4

High-throughput

0.536

High

131367

RB
Retinoblastoma-associated protein

1

1

High-throughput

0.536

High

131384

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.536

High

131396

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

131403

NU153
Nuclear pore complex protein Nup153

1

20

High-throughput

0.536

High

131404

RBP2
E3 SUMO-protein ligase RanBP2

1

9

High-throughput

0.536

High

131405

SMCA4
Transcription activator BRG1

1

20

High-throughput

0.536

High

131409

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

131410

RRP1
Ribosomal RNA processing protein 1 homolog A

1

1

High-throughput

0.536

High

131415

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.536

High

131418

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.536

High

131425

ILF3
Interleukin enhancer-binding factor 3

1

4

High-throughput

0.536

High

131432

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.536

High

131438

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

131443

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

131481

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

131492

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.536

High

131512

PHAX
Phosphorylated adapter RNA export protein

1

3

High-throughput

0.536

High

131519

MRGBP
MRG/MORF4L-binding protein

1

2

High-throughput

0.536

High

131520

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.536

High

131523

SAE1
SUMO-activating enzyme subunit 1

1

2

High-throughput

0.536

High

131378

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

High-throughput

0.515

High

131385

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.515

High

131402

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.515

High

131452

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.515

High

131488

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.515

High

131514

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

3

High-throughput

0.515

High

131375

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

131343

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

131380

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

14

Small-scale

0.501

High

131408

ZN131
Zinc finger protein 131

1

9

Small-scale

0.501

High

131446

HIF1A
Hypoxia-inducible factor 1-alpha

1

13

Small-scale

0.501

High

131501

EPAS1
Endothelial PAS domain-containing protein 1

1

13

Small-scale

0.501

High

131399

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.500

High

131383

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.494

High

131353

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.489

High

131428

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.481

High

131435

MVP
Major vault protein

1

2

High-throughput

0.481

High

131460

ANR11
Ankyrin repeat domain-containing protein 11

1

9

High-throughput

0.481

High

131526

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

4

Small-scale

0.481

High

72690

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

15

High-throughput

0.479

High

122355

MEN1
Menin

1

1

High-throughput

0.479

High

124990

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

131340

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

131342

MDM4
Protein Mdm4

1

2

Small-scale

0.479

High

131345

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

131348

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

131349

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

131354

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

131355

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

10

Small-scale

0.479

High

131357

PCNT
Pericentrin

1

2

High-throughput

0.479

High

131358

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

131363

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

131364

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

131374

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

131379

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

131381

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

131387

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

131388

NU214
Nuclear pore complex protein Nup214

1

7

Small-scale

0.479

High

131392

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

131393

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

131400

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.479

High

131411

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

131413

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

131423

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.479

High

131424

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

131426

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

131427

GRM1
Metabotropic glutamate receptor 1

1

1

Small-scale

0.479

High

131434

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

131440

KS6A2
Ribosomal protein S6 kinase alpha-2

1

5

High-throughput

0.479

High

131441

PCBP1
Poly(rC)-binding protein 1

1

3

High-throughput

0.479

High

131444

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

131447

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

131451

AKIR2
Akirin-2

1

3

Small-scale

0.479

High

131455

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

131458

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

131464

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

131467

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

131469

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

6

Small-scale

0.479

High

131473

COP1
E3 ubiquitin-protein ligase COP1

1

15

High-throughput

0.479

High

131478

DDB2
DNA damage-binding protein 2

1

6

High-throughput

0.479

High

131479

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

131484

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

131485

MRTFA
Myocardin-related transcription factor A

1

1

Small-scale

0.479

High

131487

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

131498

NACC1
Nucleus accumbens-associated protein 1

1

16

Small-scale

0.479

High

131500

BARD1
BRCA1-associated RING domain protein 1

1

9

High-throughput

0.479

High

131507

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

131508

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

131509

AICDA
Single-stranded DNA cytosine deaminase

1

5

Small-scale

0.479

High

131511

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

131516

SENP2
Sentrin-specific protease 2

1

4

Small-scale

0.479

High

131522

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

131524

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.479

High

131525

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

131528

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

11

High-throughput

0.479

High

131530

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

72223

B3KTP4
Apolipoprotein L, 6

1

1

High-throughput

0.470

High

131502

Q9BRL8
MTA1 protein

1

9

High-throughput

0.470

High

131534

X5D778
Ankyrin repeat domain 11 isoform A

1

9

High-throughput

0.470

High

131386

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.460

High

131356

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

131382

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

131454

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

131472

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

131476

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

131486

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

131506

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

131442

SF01
Splicing factor 1

1

5

High-throughput

0.457

High

131535

X5D7R7
Major vault protein isoform G

1

2

High-throughput

0.457

High

65033

P121C
Nuclear envelope pore membrane protein POM 121C

1

14

High-throughput

0.445

High

131372

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

131453

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

131457

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

131471

ZBT34
Zinc finger and BTB domain-containing protein 34

1

18

Small-scale

0.445

High

131491

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.445

High

131497

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

131529

AKP8L
A-kinase anchor protein 8-like

1

3

High-throughput

0.445

High

131505

APOL6
Apolipoprotein L6

1

1

High-throughput

0.439

High

131518

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

131359

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

131365

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

131461

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

131465

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.437

High

131510

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

131513

F204A
Protein FAM204A

1

1

High-throughput

0.437

High

131477

SC5AB
Sodium/myo-inositol cotransporter 2

2

0

High-throughput

0.341

High

131475

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.299

High

131371

TM276
Transmembrane protein 276

1

0

High-throughput

0.268

Low

131531

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024