Protein: DCAF8
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)

Gene: DCAF8
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q5TAQ9

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157757

DDB1
DNA damage-binding protein 1

16

20

Small-scale

0.984

High

1215359

DDA1
DET1- and DDB1-associated protein 1

4

7

Small-scale

0.881

High

1007065

TCPB
T-complex protein 1 subunit beta

3

20

High-throughput

0.855

High

1215390

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

3

4

High-throughput

0.855

High

65460

DC8L1
DDB1- and CUL4-associated factor 8-like protein 1

2

18

High-throughput

0.811

High

610704

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.811

High

881964

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.811

High

899427

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.811

High

1215336

TCPW
T-complex protein 1 subunit zeta-2

2

20

High-throughput

0.811

High

1215355

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.811

High

1215367

WDR76
WD repeat-containing protein 76

2

19

Small-scale

0.806

High

1114878

CUL4A
Cullin-4A

11

20

Small-scale

0.755

High

1115246

CUL4B
Cullin-4B

8

20

Small-scale

0.749

High

1215372

HELLS
Lymphoid-specific helicase

1

20

Small-scale

0.747

High

216455

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

7

High-throughput

0.740

High

1215353

MDFI
MyoD family inhibitor

4

1

High-throughput

0.709

High

821398

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.691

High

846755

GRK6
G protein-coupled receptor kinase 6

1

8

High-throughput

0.691

High

876004

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.691

High

245970

KIF1B
Kinesin-like protein KIF1B

1

6

High-throughput

0.665

High

822704

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.665

High

1030316

AMPD2
AMP deaminase 2

3

1

High-throughput

0.662

High

1215313

ACD11
Acyl-CoA dehydrogenase family member 11

3

2

High-throughput

0.662

High

1215341

CSN5
COP9 signalosome complex subunit 5

3

9

High-throughput

0.650

High

241940

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.650

High

1215332

TFB1M
Dimethyladenosine transferase 1, mitochondrial

2

1

High-throughput

0.628

High

1215347

ARHGQ
Rho guanine nucleotide exchange factor 26

2

10

High-throughput

0.628

High

1215348

REXO5
RNA exonuclease 5

2

6

High-throughput

0.628

High

1215368

E41L5
Band 4.1-like protein 5

2

7

High-throughput

0.628

High

1215315

CSN6
COP9 signalosome complex subunit 6

3

7

High-throughput

0.624

High

1215340

GGH
Gamma-glutamyl hydrolase

3

0

High-throughput

0.622

High

1142077

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.618

High

194230

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.618

High

957415

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.618

High

970639

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.618

High

1215311

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.618

High

1215312

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1215362

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

16

High-throughput

0.618

High

1215382

FBW1B
F-box/WD repeat-containing protein 11

1

18

High-throughput

0.618

High

75761

B3KW44
tRNA N(3)-cytidine methyltransferase

2

1

High-throughput

0.611

High

1186169

INAVA
Innate immunity activator protein

2

0

High-throughput

0.602

High

172916

XPO1
Exportin-1

2

20

Small-scale

0.601

High

109417

G5E9A7
DM1 locus, WD repeat containing

1

20

High-throughput

0.594

High

400972

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

8

Small-scale

0.586

High

1215380

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

1215308

TENS2
Tensin-2

2

8

High-throughput

0.576

High

1215338

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.576

High

1215344

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

18

High-throughput

0.575

High

1215356

ANM1
Protein arginine N-methyltransferase 1

1

9

High-throughput

0.573

High

1215373

THAP1
THAP domain-containing protein 1

1

3

High-throughput

0.573

High

858675

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

9

High-throughput

0.571

High

958654

CSN2
COP9 signalosome complex subunit 2

2

15

High-throughput

0.571

High

1215386

CSN3
COP9 signalosome complex subunit 3

2

14

High-throughput

0.571

High

1215361

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.568

High

1142492

PDCD1
Programmed cell death protein 1

1

1

Small-scale

0.553

High

1215330

DPTOR
DEP domain-containing mTOR-interacting protein

1

3

Small-scale

0.553

High

1215342

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

943252

RBM11
Splicing regulator RBM11

1

10

High-throughput

0.541

High

1215345

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

8

High-throughput

0.541

High

582833

EZRI
Ezrin

1

7

High-throughput

0.536

High

909037

NEK4
Serine/threonine-protein kinase Nek4

1

10

High-throughput

0.536

High

951202

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.536

High

981531

RAN
GTP-binding nuclear protein Ran

1

6

High-throughput

0.536

High

1051006

FAK1
Focal adhesion kinase 1

1

8

High-throughput

0.536

High

1106200

MYO9B
Unconventional myosin-IXb

1

11

High-throughput

0.536

High

1119431

PDE7A
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

1

4

High-throughput

0.536

High

1192941

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

8

High-throughput

0.536

High

1215309

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.536

High

1215317

PODN
Podocan

1

4

High-throughput

0.536

High

1215370

PAK6
Serine/threonine-protein kinase PAK 6

1

4

High-throughput

0.536

High

1215375

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.536

High

911267

IMA5
Importin subunit alpha-5

1

5

Small-scale

0.534

High

1215323

S15A3
Solute carrier family 15 member 3

2

1

High-throughput

0.521

High

1134228

IMB1
Importin subunit beta-1

1

8

Small-scale

0.515

High

231712

PEX1
Peroxisomal ATPase PEX1

1

6

High-throughput

0.515

High

415627

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.515

High

451176

NFL
Neurofilament light polypeptide

1

8

High-throughput

0.515

High

767237

MERL
Merlin

1

7

High-throughput

0.515

High

1025116

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.515

High

1031908

NC2B
Protein Dr1

1

3

High-throughput

0.515

High

1096037

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.515

High

1215318

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1215389

RNF11
RING finger protein 11

1

2

High-throughput

0.515

High

1215391

TF3C3
General transcription factor 3C polypeptide 3

1

14

High-throughput

0.515

High

702785

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.514

High

754039

CD80
T-lymphocyte activation antigen CD80

1

2

High-throughput

0.514

High

1128635

ZN460
Zinc finger protein 460

1

0

High-throughput

0.513

High

1215314

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.513

High

1215376

STOX2
Storkhead-box protein 2

1

0

High-throughput

0.513

High

1215388

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.513

High

891191

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.508

High

384438

CRYAA
Alpha-crystallin A chain

1

5

High-throughput

0.501

High

1215378

SPAST
Spastin

1

9

Small-scale

0.501

High

1215343

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.500

High

216713

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

1215316

LYZL2
Lysozyme-like protein 2

1

1

High-throughput

0.489

High

1215325

CBPA6
Carboxypeptidase A6

1

1

High-throughput

0.489

High

1215385

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.489

High

166531

BACH1
Transcription regulator protein BACH1

1

11

Small-scale

0.479

High

342215

BRD1
Bromodomain-containing protein 1

1

10

High-throughput

0.479

High

347088

BAG2
BAG family molecular chaperone regulator 2

1

5

Small-scale

0.479

High

372254

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

587694

DESP
Desmoplakin

1

20

High-throughput

0.479

High

596145

H12
Histone H1.2

1

13

High-throughput

0.479

High

606848

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

611168

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

637561

FLNA
Filamin-A

1

15

High-throughput

0.479

High

664763

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.479

High

830890

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

942676

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.479

High

983834

RBX1
E3 ubiquitin-protein ligase RBX1

1

7

Small-scale

0.479

High

995081

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.479

High

1106572

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.479

High

1107808

SQSTM
Sequestosome-1

1

8

High-throughput

0.479

High

1135707

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1153538

MLF2
Myeloid leukemia factor 2

1

1

Small-scale

0.479

High

1161299

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

Small-scale

0.479

High

1163724

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

12

High-throughput

0.479

High

1178187

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1192033

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

Small-scale

0.479

High

1215319

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

1215326

CE120
Centrosomal protein of 120 kDa

1

19

High-throughput

0.479

High

1215334

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.479

High

1215337

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1215339

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1215364

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

705394

GRN
Progranulin

1

1

High-throughput

0.470

High

1215321

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

1215333

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

1215371

ANM8
Protein arginine N-methyltransferase 8

1

9

High-throughput

0.464

High

551087

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

719153

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

1215346

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

1215350

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.458

High

1215392

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

1215393

DNM3A
DNA

1

0

Small-scale

0.458

High

66834

RFPLA
Ret finger protein-like 4A

1

2

High-throughput

0.445

High

171475

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

182137

PFD6
Prefoldin subunit 6

1

8

High-throughput

0.445

High

253160

MOT2
Monocarboxylate transporter 2

1

3

High-throughput

0.445

High

625437

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.445

High

963307

PFD3
Prefoldin subunit 3

1

9

High-throughput

0.445

High

972446

RS14
Small ribosomal subunit protein uS11

1

9

High-throughput

0.445

High

1094349

CSN1
COP9 signalosome complex subunit 1

1

13

High-throughput

0.445

High

1129236

LAGE3
EKC/KEOPS complex subunit LAGE3

1

1

High-throughput

0.445

High

1215324

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.445

High

1215335

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

1215351

PFD5
Prefoldin subunit 5

1

8

High-throughput

0.445

High

1215352

CSN8
COP9 signalosome complex subunit 8

1

3

High-throughput

0.445

High

1215354

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

4

High-throughput

0.445

High

1215357

MICU1
Calcium uptake protein 1, mitochondrial

1

6

High-throughput

0.445

High

1215358

CSN4
COP9 signalosome complex subunit 4

1

3

High-throughput

0.445

High

1215365

METL8
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial

1

1

High-throughput

0.445

High

1215366

NOL11
Nucleolar protein 11

1

3

High-throughput

0.445

High

1215379

CSN7A
COP9 signalosome complex subunit 7a

1

7

High-throughput

0.445

High

106084

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1010640

DCD
Dermcidin

1

2

High-throughput

0.437

High

1215349

DNJC1
DnaJ homolog subfamily C member 1

1

14

High-throughput

0.437

High

1215374

DJC28
DnaJ homolog subfamily C member 28

1

1

High-throughput

0.437

High

1215381

ZNHI2
Zinc finger HIT domain-containing protein 2

1

1

High-throughput

0.437

High

1215383

PNMA2
Paraneoplastic antigen Ma2

1

2

Small-scale

0.437

High

1215328

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.426

High

104173

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

168860

PLD2
Phospholipase D2

1

1

High-throughput

0.407

High

337749

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

877677

SL9A3
Sodium/hydrogen exchanger 3

1

3

High-throughput

0.407

High

1157362

EXT1
Exostosin-1

1

3

High-throughput

0.407

High

1215320

SO6A1
Solute carrier organic anion transporter family member 6A1

1

4

High-throughput

0.407

High

1215327

SYT2
Synaptotagmin-2

1

2

High-throughput

0.407

High

1215331

S35F5
Solute carrier family 35 member F5

1

1

High-throughput

0.407

High

1215369

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.407

High

1215377

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.407

High

1215384

S39AA
Zinc transporter ZIP10

1

2

High-throughput

0.407

High

1215310

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

866435

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

0

High-throughput

0.279

Low

1215307

LIPK
Lipase member K

1

0

High-throughput

0.279

Low

1215363

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

301469

WFS1
Wolframin

1

0

High-throughput

0.268

Low

327058

NXPH3
Neurexophilin-3

1

0

High-throughput

0.232

Low

1215322

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

0

High-throughput

0.232

Low

1215329

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1215360

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low

1215387

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025