HitPredict

Interactor 1: SDCB1 (O00560)
Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)
Gene: SDCBP

Interactor 2: GRIK2 (Q13002)
Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
Gene: GRIK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	12597860
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 908
+	Hs
		132760 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		GRIK1_HUMAN (14-854): 0: 874: 80.26
+	Rn
		611608 SDCB1_RAT (1-298): 2.61e-101: 300: 89.33		GRIK1_RAT (14-890): 0: 873: 76.68
+	Hs
		132765 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		GRIA3_HUMAN (8-863): 0: 764: 39.02
+	Hs
		132763 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		GRIA1_HUMAN (15-854): 0: 763: 39.46
+	Hs
		132771 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		GRIA4_HUMAN (12-887): 0: 756: 37.39
+	Rn
		585196 SDCB1_RAT (1-298): 2.61e-101: 300: 89.33		GRIA3_RAT (8-863): 0: 761: 38.91
+	Rn
		585157 SDCB1_RAT (1-298): 2.61e-101: 300: 89.33		GRIA1_RAT (14-854): 0: 759: 39.54
+	Hs
		132764 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		GRIA2_HUMAN (13-863): 0: 746: 38.33
+	Rn
		585219 SDCB1_RAT (1-298): 2.61e-101: 300: 89.33		GRIA4_RAT (12-887): 0: 755: 37.28
+	Hs
		1022366 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		GRIK2_HUMAN (1-908): 0: 965: 100.00
+	Rn
		585184 SDCB1_RAT (1-298): 2.61e-101: 300: 89.33		GRIA2_RAT (13-863): 0: 743: 38.22
+	Hs
		761199 DLG4_HUMAN (193-286): 2.16e-16: 81.4: 24.75		GRIK1_HUMAN (14-854): 0: 874: 80.26
+	Mm
		620904 DLG2_MOUSE (6-268): 1.74e-19: 90.6: 15.93		GRIA1_MOUSE (14-854): 0: 756: 39.54
+	Mm
		620881 DLG3_MOUSE (184-268): 2.19e-17: 84.4: 26.09		GRIA1_MOUSE (14-854): 0: 756: 39.54
+	Hs
		1081918 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		GRIK5_HUMAN (20-902): 0: 704: 43.83
+	Rn
		1144131 DLG2_RAT (6-268): 2.34e-19: 90.2: 15.93		GRID2_RAT (12-907): 0: 609: 26.55
+	Mm
		723606 DLG2_MOUSE (6-268): 1.74e-19: 90.6: 15.93		NMDZ1_MOUSE (11-906): 0: 601: 22.88
+	Rn
		723628 DLG3_RAT (184-268): 2.07e-17: 84.4: 26.09		NMDZ1_RAT (11-906): 0: 602: 22.99
+	Mm
		723568 DLG3_MOUSE (184-268): 2.19e-17: 84.4: 26.09		NMDZ1_MOUSE (11-906): 0: 601: 22.88
+	Rn
		1143996 DLG2_RAT (6-268): 2.34e-19: 90.2: 15.93		GRID1_RAT (13-886): 0: 584: 27.53