HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	35271311, 19380743, 26186194, 28514442, 33961781, 24189400
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 435
+	Hs
		1287515 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		787954 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Hs
		1078888 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Rn
		64454 A7BFV9_RAT (1-896): 6.97e-140: 440: 89.42		Q7TNJ9_RAT (127-408): 1.81e-58: 205: 23.26
+	Ce
		725368 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95
+	Hs
		1287519 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		1287516 EHD2_HUMAN (19-102): 1.88e-12: 72.7: 27.38		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		1349325 EHD2_HUMAN (19-102): 1.88e-12: 72.7: 27.38		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	Hs
		1078883 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Dm
		91158 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		STNB_DROME (118-433): 1.17e-60: 215: 18.80
+	Hs
		1263435 EHD1_HUMAN (17-102): 8.74e-16: 83.5: 33.72		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Hs
		1263440 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85