HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 639
+	Hs
		924862 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1153477 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		209049 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		292690 GAB1_MOUSE (52-611): 1.35e-53: 199: 15.45		GRAP2_MOUSE (2-328): 2.38e-46: 168: 15.27
+	Hs
		275195 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		253366 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Mm
		1141170 GAB1_MOUSE (52-611): 1.35e-53: 199: 15.45		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		924547 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		253347 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		924640 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		596390 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924651 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924637 CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557681 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		1153260 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		557601 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		557714 RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		235528 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Mm
		1194490 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17
+	Ce
		1095336 Q23419_CAEEL (46-578): 5.81e-41: 163: 12.59		Q6A573_CAEEL (4-271): 6.86e-18: 89.3: 20.95