Protein: MLH3
DNA mismatch repair protein MLH3 (MutL protein homolog 3)

Gene: MLH3
Organism: Saccharomyces cerevisiae S288C
Interactions: 144
UniProt ID: Q12083

Gene Ontology (top 5):
GO:0000710 - meiotic mismatch repair
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006298 - mismatch repair
GO:0007131 - reciprocal meiotic recombination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

757826

MLH1
DNA mismatch repair protein MLH1

13

13

Small-scale

0.983

High

1014995

MSH5
MutS protein homolog 5

1

20

Small-scale

0.647

High

536224

PMS1
DNA mismatch repair protein PMS1

1

13

High-throughput

0.618

High

1014992

MLH3
DNA mismatch repair protein MLH3

1

13

High-throughput

0.618

High

715661

SGS1
ATP-dependent helicase SGS1

1

3

Small-scale

0.534

High

866100

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

0

High-throughput

0.513

High

389336

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

423927

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.500

High

556363

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.500

High

570730

HXKG
Glucokinase-1

1

1

High-throughput

0.500

High

887711

ACT
Actin

1

2

High-throughput

0.500

High

381498

GAL1
Galactokinase

1

0

High-throughput

0.479

High

498615

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

588258

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

412599

CDC7
Cell division control protein 7

1

2

High-throughput

0.479

High

546225

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

550582

PCNA
Proliferating cell nuclear antigen

1

5

High-throughput

0.479

High

558311

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

577185

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

4

High-throughput

0.479

High

578574

SEC18
Vesicular-fusion protein SEC18

1

2

High-throughput

0.479

High

593570

DBP3
ATP-dependent RNA helicase DBP3

1

1

High-throughput

0.479

High

663609

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

675569

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

693174

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

High-throughput

0.479

High

747258

SIF2
SIR4-interacting protein SIF2

1

1

High-throughput

0.479

High

751150

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.479

High

751345

RFC1
Replication factor C subunit 1

1

6

Small-scale

0.479

High

764589

EXO1
Exodeoxyribonuclease 1

1

5

High-throughput

0.479

High

774248

MET18
DNA repair/transcription protein MET18/MMS19

1

3

High-throughput

0.479

High

811971

ARP3
Actin-related protein 3

1

3

High-throughput

0.479

High

865701

RHO5
GTP-binding protein RHO5

1

2

High-throughput

0.479

High

975549

RLI1
Translation initiation factor RLI1

1

1

High-throughput

0.479

High

977539

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.479

High

978363

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

994433

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.479

High

1014993

RTK1
Probable serine/threonine-protein kinase RTK1

1

3

High-throughput

0.479

High

343210

TRP
Tryptophan synthase

1

0

High-throughput

0.458

High

375633

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.458

High

416104

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.458

High

423551

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

608491

SAN1
Protein SAN1

1

0

High-throughput

0.458

High

630621

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

679728

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.458

High

680302

VATC
V-type proton ATPase subunit C

1

0

High-throughput

0.458

High

686987

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

687575

PYC2
Pyruvate carboxylase 2

1

0

High-throughput

0.458

High

689060

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

701193

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.458

High

707254

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.458

High

710838

CASP
Protein CASP

1

0

High-throughput

0.458

High

715751

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

731368

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.458

High

745557

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.458

High

747658

HSL7
Protein arginine N-methyltransferase HSL7

1

0

High-throughput

0.458

High

752307

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.458

High

752990

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.458

High

753094

SYRM
Arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

763195

FHP
Flavohemoprotein

1

0

High-throughput

0.458

High

777421

YAP4
AP-1-like transcription factor YAP4

1

0

High-throughput

0.458

High

784710

THI6
Thiamine biosynthetic bifunctional enzyme [Includes: Thiamine-phosphate synthase

1

0

High-throughput

0.458

High

796947

GCN20
Protein GCN20

1

0

High-throughput

0.458

High

798005

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.458

High

858825

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

860161

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.458

High

865220

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

0

High-throughput

0.458

High

977822

FIN1
Filament protein FIN1

1

0

High-throughput

0.458

High

979803

APC4
Anaphase-promoting complex subunit 4

1

0

High-throughput

0.458

High

982952

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.458

High

985324

VID22
Vacuolar import and degradation protein 22

1

0

High-throughput

0.458

High

986202

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

987599

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

996179

ESA1
Histone acetyltransferase ESA1

1

0

High-throughput

0.458

High

1014994

CFT2
Cleavage factor two protein 2

1

0

High-throughput

0.458

High

1014997

IES3
Ino eighty subunit 3

1

0

High-throughput

0.458

High

1015000

H2AZ
Histone H2A.Z

1

0

High-throughput

0.458

High

1015001

YPK9
Vacuolar cation-transporting ATPase YPK9

1

0

High-throughput

0.458

High

513110

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

633673

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

695753

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

769741

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

523321

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.437

High

744033

YMC2
Carrier protein YMC2, mitochondrial

1

1

High-throughput

0.437

High

767440

UTP7
U3 small nucleolar RNA-associated protein 7

1

1

High-throughput

0.437

High

859589

MLC1
Myosin light chain 1

1

1

High-throughput

0.437

High

861468

MTM1
Mitochondrial carrier protein MTM1

1

1

High-throughput

0.437

High

959895

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

972449

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.437

High

992647

PSR2
Probable phosphatase PSR2

1

1

High-throughput

0.437

High

996994

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

424245

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.279

Low

1014996

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.265

Low

343707

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

361074

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

521074

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

141571

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

141651

COQ4
Ubiquinone biosynthesis protein COQ4, mitochondrial

1

0

High-throughput

0.249

Low

357385

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

439693

SPS2
Sporulation-specific protein 2

1

0

High-throughput

0.249

Low

509203

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.249

Low

520458

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

533773

RSR1
Ras-related protein RSR1

1

0

High-throughput

0.249

Low

629496

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

0

High-throughput

0.249

Low

681336

TPS2
Trehalose-phosphatase

1

0

High-throughput

0.249

Low

696604

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.249

Low

700018

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

704953

PGM1
Phosphoglucomutase 1

1

0

High-throughput

0.249

Low

715534

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.249

Low

727675

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.249

Low

740841

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

743484

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

0

High-throughput

0.249

Low

745536

MRX3
MIOREX complex component 3

1

0

High-throughput

0.249

Low

747238

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.249

Low

749091

YB8B
Uncharacterized transporter YBR287W

1

0

High-throughput

0.249

Low

753733

OSH7
Oxysterol-binding protein homolog 7

1

0

High-throughput

0.249

Low

753779

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.249

Low

755079

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

755967

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.249

Low

766410

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

767347

AIM9
Altered inheritance of mitochondria protein 9, mitochondrial

1

0

High-throughput

0.249

Low

772741

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.249

Low

773887

COA1
Cytochrome c oxidase assembly factor 1

1

0

High-throughput

0.249

Low

774469

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.249

Low

797052

EMP47
Protein EMP47

1

0

High-throughput

0.249

Low

798307

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.249

Low

809682

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.249

Low

810009

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

High-throughput

0.249

Low

838449

SIP18
Protein SIP18

1

0

High-throughput

0.249

Low

846319

RL9B
Large ribosomal subunit protein uL6B

1

0

High-throughput

0.249

Low

864530

YN8O
Uncharacterized protein YNR040W

1

0

High-throughput

0.249

Low

978087

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.249

Low

978527

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.249

Low

982819

NTE1
Lysophospholipase NTE1

1

0

High-throughput

0.249

Low

982980

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

0

High-throughput

0.249

Low

984795

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.249

Low

985779

STE23
A-factor-processing enzyme

1

0

High-throughput

0.249

Low

988714

CDA1
Chitin deacetylase 1

1

0

High-throughput

0.249

Low

991149

MRX9
MIOREX complex component 9

1

0

High-throughput

0.249

Low

992228

FRA1
Putative Xaa-Pro aminopeptidase FRA1

1

0

High-throughput

0.249

Low

994480

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.249

Low

996270

GPN2
GPN-loop GTPase 2

1

0

High-throughput

0.249

Low

997025

PGC1
Phosphatidylglycerol phospholipase C

1

0

High-throughput

0.249

Low

1014998

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.249

Low

1014999

PRM4
Pheromone-regulated membrane protein 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024