HitPredict

Interactor 1: ARNT2 (Q9HBZ2)
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)
Gene: ARNT2

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	24722188
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 717 Hs			1 1424
+	Hs
		1085690 ARNT2_HUMAN (1-717): 0: 697: 100.00		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		1306192 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		946354 ARNT2_HUMAN (1-717): 0: 697: 100.00		SIM1_HUMAN (27-710): 7.05e-104: 351: 15.28
+	Hs
		1306541 ARNT2_HUMAN (1-717): 0: 697: 100.00		EPAS1_HUMAN (12-878): 3.88e-100: 343: 13.27
+	Mm
		1142081 ARNT2_MOUSE (1-717): 0: 683: 97.07		SIM1_MOUSE (27-710): 3.29e-100: 340: 14.62
+	Hs
		1050587 ARNT2_HUMAN (1-717): 0: 697: 100.00		SIM2_HUMAN (27-690): 1.22e-88: 305: 14.79
+	Hs
		1085741 X5DP31_HUMAN (1-624): 0: 617: 94.88		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		1220557 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS3_HUMAN (20-732): 1.75e-82: 294: 12.29
+	Hs
		1335644 ARNT2_HUMAN (1-717): 0: 697: 100.00		X5D985_HUMAN (19-732): 6.44e-81: 288: 12.27
+	Hs
		1335647 ARNT2_HUMAN (1-717): 0: 697: 100.00		X5DR67_HUMAN (5-732): 2.96e-80: 287: 11.82
+	Hs
		1220558 X5D7T2_HUMAN (1-691): 0: 668: 98.99		NPAS3_HUMAN (20-732): 1.75e-82: 294: 12.29
+	Hs
		1378460 X5D7T2_HUMAN (1-691): 0: 668: 98.99		X5D985_HUMAN (19-732): 6.44e-81: 288: 12.27
+	Hs
		1378461 X5D7T2_HUMAN (1-691): 0: 668: 98.99		X5DR67_HUMAN (5-732): 2.96e-80: 287: 11.82
+	Hs
		728962 ARNT2_HUMAN (1-717): 0: 697: 100.00		AHR_HUMAN (12-793): 4.1e-70: 255: 12.66
+	Hs
		1220559 X5DP31_HUMAN (1-624): 0: 617: 94.88		NPAS3_HUMAN (20-732): 1.75e-82: 294: 12.29
+	Hs
		1378465 X5DP31_HUMAN (1-624): 0: 617: 94.88		X5D985_HUMAN (19-732): 6.44e-81: 288: 12.27
+	Mm
		864790 ARNT_MOUSE (4-717): 0: 546: 56.20		EPAS1_MOUSE (12-872): 5.54e-91: 317: 13.77
+	Mm
		101520 ARNT_MOUSE (4-717): 0: 546: 56.20		F8VQB2_MOUSE (20-702): 5.36e-83: 295: 11.47
+	Mm
		864789 ARNT_MOUSE (4-717): 0: 546: 56.20		NPAS1_MOUSE (10-548): 1.07e-79: 277: 15.84
+	Mm
		674910 ARNT_MOUSE (4-717): 0: 546: 56.20		AHR_MOUSE (12-766): 2.12e-72: 262: 14.02