HitPredict

Interactor 1: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Interactor 2: DICER (Q9UPY3)
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
Gene: DICER1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 619 Hs			1 1922
+	Hs
		996878 SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89		IFIH1_HUMAN (33-641): 7.5e-85: 304: 19.44
+	Hs
		571557 CIC_HUMAN (43-578): 1.85e-33: 139: 15.01		DDX5_HUMAN (6-364): 3.03e-66: 239: 11.54
+	Hs
		571415 SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89		DDX5_HUMAN (6-364): 3.03e-66: 239: 11.54
+	Hs
		571352 SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69		DDX5_HUMAN (6-364): 3.03e-66: 239: 11.54
+	Mm
		818738 SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15		Q8BTS0_MOUSE (6-364): 3.1e-66: 239: 11.54
+	Hs
		757585 SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89		IF4A3_HUMAN (6-251): 1.27e-52: 193: 11.37
+	Hs
		757505 SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69		IF4A3_HUMAN (6-251): 1.27e-52: 193: 11.37
+	Hs
		272250 CIC_HUMAN (43-578): 1.85e-33: 139: 15.01		U520_HUMAN (4-505): 1.16e-29: 132: 10.93
+	Hs
		818246 SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69		ASCC3_HUMAN (13-493): 5.92e-31: 136: 11.18
+	Hs
		272110 SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89		U520_HUMAN (4-505): 1.16e-29: 132: 10.93
+	Hs
		996917 SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89		RNC_HUMAN (1311-1374): 1.17e-12: 75.8: 32.81