HitPredict

Interactor 1: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	33961781, 32203420, 35271311, 22558309, 20697350
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016197 - endosomal transport
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1697 Hs			1 864
+	Hs
		61738 A6H8W8_HUMAN (2-1697): 0: 946: 98.35		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		787985 ITSN2_HUMAN (1-1697): 0: 969: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		1078923 ITSN1_HUMAN (2-1693): 0: 863: 56.23		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		61732 A6H8W8_HUMAN (2-1697): 0: 946: 98.35		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		1141846 ITSN1_MOUSE (2-1693): 0: 861: 56.37		EP15R_MOUSE (1-862): 1.06e-124: 399: 92.11
+	Hs
		787920 ITSN1_HUMAN (2-1693): 0: 863: 56.23		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Cl
		47357 F1PHV6_CANLF (2-1693): 0: 875: 56.51		A0A8I3PJA6_CANLF (1-862): 1.93e-105: 348: 41.45
+	Mm
		788010 ITSN1_MOUSE (2-1693): 0: 861: 56.37		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		1078919 ITSN2_HUMAN (1-1697): 0: 969: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1349275 ITSN2_HUMAN (1-1697): 0: 969: 100.00		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		1078828 ITSN1_HUMAN (2-1693): 0: 863: 56.23		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		92844 ITSN1_RAT (2-1693): 0: 854: 56.08		E9PSY8_RAT (9-312): 6.07e-16: 84.7: 15.41
+	Hs
		1078872 ITSN1_HUMAN (2-1693): 0: 863: 56.23		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42
+	Hs
		787987 EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		1078876 PREX1_HUMAN (1167-1594): 2.68e-68: 257: 19.20		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		279897 TRIO_HUMAN (205-1561): 3.77e-74: 277: 10.84		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Dm
		91151 M9ND00_DROME (1-447): 2.52e-32: 139: 14.35		E3CTP7_DROME (504-831): 1.9e-12: 73.2: 8.54