Protein: NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)

Gene: NHRF1, NHERF1
Organism: Homo sapiens
Interactions: 131
UniProt ID: O14745

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0002009 - morphogenesis of an epithelium
GO:0003096 - renal sodium ion transport
GO:0005102 - signaling receptor binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

162776

EZRI
Ezrin

8

20

Small-scale

0.965

High

162751

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

6

16

Small-scale

0.939

High

162796

MERL
Merlin

4

20

Small-scale

0.891

High

162784

MOES
Moesin

2

17

Small-scale

0.822

High

162775

CFTR
Cystic fibrosis transmembrane conductance regulator

14

17

Small-scale

0.765

High

162815

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

162814

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

7

14

Small-scale

0.749

High

162767

ADRB2
Beta-2 adrenergic receptor

6

20

Small-scale

0.729

High

162770

PGFRB
Platelet-derived growth factor receptor beta

4

20

Small-scale

0.704

High

783

A0A087WZU1
Phosphatidylinositol phosphatase PTPRQ

1

20

High-throughput

0.691

High

162835

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

17

High-throughput

0.691

High

162853

OTUL
Ubiquitin thioesterase otulin

1

5

High-throughput

0.691

High

162873

BAIP2
BAR/IMD domain-containing adapter protein 2

1

13

High-throughput

0.691

High

162845

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

3

17

Small-scale

0.689

High

162839

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

19

Small-scale

0.680

High

162857

TB10A
TBC1 domain family member 10A

3

8

Small-scale

0.671

High

162859

ACE2
Angiotensin-converting enzyme 2

3

4

Small-scale

0.664

High

162791

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.646

High

162805

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.646

High

162799

OPRK
Kappa-type opioid receptor

2

20

Small-scale

0.634

High

162754

MRP4
ATP-binding cassette sub-family C member 4

2

9

Small-scale

0.629

High

162794

CTNB1
Catenin beta-1

2

13

Small-scale

0.624

High

162812

EPHB1
Ephrin type-B receptor 1

1

20

Small-scale

0.618

High

162813

RAB25
Ras-related protein Rab-25

1

7

High-throughput

0.618

High

162816

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

162834

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

162844

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

162781

CRCM
Colorectal mutant cancer protein

2

6

Small-scale

0.611

High

162821

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

2

4

Small-scale

0.611

High

162851

APBP2
Amyloid protein-binding protein 2

2

3

High-throughput

0.606

High

162852

MRP2
ATP-binding cassette sub-family C member 2

2

9

Small-scale

0.602

High

162756

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

16

Small-scale

0.601

High

162795

NOS2
Nitric oxide synthase, inducible

2

6

Small-scale

0.600

High

162861

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

2

4

Small-scale

0.584

High

162779

PGFRA
Platelet-derived growth factor receptor alpha

1

19

Small-scale

0.578

High

162842

RHG17
Rho GTPase-activating protein 17

2

18

Small-scale

0.565

High

162766

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.561

High

162790

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

5

Small-scale

0.561

High

162792

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.561

High

162798

TCF7
Transcription factor 7

1

5

Small-scale

0.561

High

162822

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

20

Small-scale

0.561

High

162806

P2RY1
P2Y purinoceptor 1

1

20

Small-scale

0.554

High

162788

RABP1
Cellular retinoic acid-binding protein 1

2

1

High-throughput

0.553

High

162874

DLGP4
Disks large-associated protein 4

2

20

High-throughput

0.553

High

162761

BCL10
B-cell lymphoma/leukemia 10

1

1

High-throughput

0.541

High

162836

B2LA1
Bcl-2-related protein A1

1

0

High-throughput

0.536

High

141881

PODXL
Podocalyxin

1

10

High-throughput

0.536

High

162759

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

162783

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

High-throughput

0.536

High

162811

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

High-throughput

0.536

High

162825

SRSF1
Serine/arginine-rich splicing factor 1

1

1

High-throughput

0.536

High

162826

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.536

High

162832

KCTD2
BTB/POZ domain-containing protein KCTD2

1

20

High-throughput

0.536

High

162850

PSMF1
Proteasome inhibitor PI31 subunit

1

2

High-throughput

0.536

High

162868

ARL15
ADP-ribosylation factor-like protein 15

1

9

High-throughput

0.536

High

162869

KCTD5
BTB/POZ domain-containing protein KCTD5

1

20

High-throughput

0.536

High

162875

GIT1
ARF GTPase-activating protein GIT1

1

20

High-throughput

0.536

High

162768

YES
Tyrosine-protein kinase Yes

1

15

Small-scale

0.527

High

162810

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

Small-scale

0.527

High

162758

HEXI1
Protein HEXIM1

1

0

High-throughput

0.513

High

162769

NEP
Neprilysin

1

0

Small-scale

0.513

High

162782

PRPH2
Peripherin-2

1

0

High-throughput

0.513

High

162804

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.513

High

162827

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.513

High

162854

CDCA5
Sororin

1

0

High-throughput

0.513

High

162864

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

162828

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.512

High

162831

GRM2
Metabotropic glutamate receptor 2

1

12

Small-scale

0.512

High

162833

GRM3
Metabotropic glutamate receptor 3

1

9

Small-scale

0.512

High

162803

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.506

High

162780

KPCA
Protein kinase C alpha type

1

15

Small-scale

0.501

High

162830

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

162837

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

12

Small-scale

0.501

High

162858

S26A6
Solute carrier family 26 member 6

1

6

Small-scale

0.501

High

162872

FZD4
Frizzled-4

1

12

Small-scale

0.501

High

162877

S4A7
Sodium bicarbonate cotransporter 3

1

12

Small-scale

0.501

High

162762

ZBED1
E3 SUMO-protein ligase ZBED1

1

4

High-throughput

0.489

High

162838

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

3

High-throughput

0.489

High

162848

SHKB1
SH3KBP1-binding protein 1

1

20

High-throughput

0.489

High

162855

RIPR3
RIPOR family member 3

1

2

High-throughput

0.489

High

162865

ASND1
Asparagine synthetase domain-containing protein 1

1

5

High-throughput

0.489

High

162870

PDXL2
Podocalyxin-like protein 2

1

8

High-throughput

0.489

High

162876

KCTD3
BTB/POZ domain-containing protein KCTD3

1

20

High-throughput

0.489

High

162807

KCNJ1
ATP-sensitive inward rectifier potassium channel 1

1

20

Small-scale

0.481

High

162860

S13A1
Solute carrier family 13 member 1

1

2

Small-scale

0.481

High

162753

STX7
Syntaxin-7

1

5

High-throughput

0.479

High

162755

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

162763

CO3
Complement C3

1

2

High-throughput

0.479

High

162764

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

162765

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

162771

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

162772

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

162773

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

162774

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

162787

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

162789

MARCS
Myristoylated alanine-rich C-kinase substrate

1

9

High-throughput

0.479

High

162808

SL9A3
Sodium/hydrogen exchanger 3

1

6

Small-scale

0.479

High

162817

RACK1
Small ribosomal subunit protein RACK1

1

1

Small-scale

0.479

High

162820

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

162824

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.479

High

162829

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.479

High

162841

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

162871

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

162777

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

162778

CD44
CD44 antigen

1

0

Small-scale

0.458

High

162793

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

162843

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.458

High

162878

CAN6
Calpain-6

1

0

Small-scale

0.458

High

162752

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.457

High

162800

P2RY2
P2Y purinoceptor 2

1

20

Small-scale

0.457

High

162801

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

High-throughput

0.445

High

162818

RAE1L
mRNA export factor RAE1

1

2

High-throughput

0.445

High

162819

E2F1
Transcription factor E2F1

1

2

High-throughput

0.445

High

162846

S26A9
Solute carrier family 26 member 9

1

6

Small-scale

0.445

High

162847

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

Small-scale

0.445

High

162823

UBE3A
Ubiquitin-protein ligase E3A

1

15

Small-scale

0.439

High

162760

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

162802

MUC18
Cell surface glycoprotein MUC18

1

13

High-throughput

0.437

High

162856

ACON
Aconitate hydratase, mitochondrial

1

2

High-throughput

0.437

High

162809

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

162786

CD27
CD27 antigen

1

5

High-throughput

0.407

High

162862

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.407

High

162797

SCN4A
Sodium channel protein type 4 subunit alpha

1

5

Small-scale

0.373

High

162866

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

2

0

Small-scale

0.338

High

162840

ZN468
Zinc finger protein 468

1

0

High-throughput

0.282

High

162757

CCNT1
Cyclin-T1

1

0

High-throughput

0.279

Low

162849

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

162863

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.279

Low

162785

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low

162867

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025