HitPredict

Interactor 1: ARHGC (Q9NZN5)
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Gene: ARHGEF12

Interactor 2: MYO6 (Q9UM54)
Unconventional myosin-VI (Unconventional myosin-6)
Gene: MYO6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	29467281, 35271311, 26950368, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1544 Hs			1 1294
+	Hs
		1349284 ITSN2_HUMAN (608-1282): 4.01e-84: 307: 19.15		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		1078932 ITSN1_HUMAN (118-1216): 2.17e-82: 302: 13.70		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Mm
		1146471 PKHG5_MOUSE (611-1150): 2.68e-83: 299: 20.10		V9GX76_MOUSE (1-1294): 0: 1075: 95.98
+	Mm
		57810 KALRN_MOUSE (375-1440): 3.99e-71: 267: 11.52		D3YZ62_MOUSE (6-1294): 0: 902: 25.29
+	Hs
		279892 TRIO_HUMAN (776-1451): 2.3e-60: 232: 13.39		MYO10_HUMAN (3-997): 0: 878: 30.44
+	Hs
		167121 ARHGB_HUMAN (48-1455): 2.54e-146: 489: 30.06		MYO5A_HUMAN (595-1063): 4.98e-09: 63: 10.72
+	Hs
		724913 ARG28_HUMAN (154-1467): 1.55e-87: 318: 14.37		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Mm
		57875 KALRN_MOUSE (375-1440): 3.99e-71: 267: 11.52		MYO5A_MOUSE (710-1184): 1.64e-18: 94.2: 8.65