Protein: NKG2A
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)

Gene: NKG2A, KLRC1
Organism: Homo sapiens
Interactions: 167
UniProt ID: P26715

Gene Ontology (top 5):
GO:0001915 - negative regulation of T cell mediated cytotoxicity
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002250 - adaptive immune response
GO:0002305 - CD8-positive, gamma-delta intraepithelial T cell differentiation
GO:0002769 - natural killer cell inhibitory signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688554

KLRD1
Natural killer cells antigen CD94

7

18

Small-scale

0.960

High

688611

KLRG1
Killer cell lectin-like receptor subfamily G member 1

2

16

High-throughput

0.783

High

688621

CLC7A
C-type lectin domain family 7 member A

2

17

High-throughput

0.783

High

688642

CLC2D
C-type lectin domain family 2 member D

2

17

High-throughput

0.783

High

688546

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

20

Small-scale

0.754

High

270202

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.691

High

688524

NKG2C
NKG2-C type II integral membrane protein

1

18

High-throughput

0.691

High

688539

EPHB4
Ephrin type-B receptor 4

1

10

High-throughput

0.691

High

688542

FCGRN
IgG receptor FcRn large subunit p51

1

20

High-throughput

0.691

High

688548

IDD
Integral membrane protein DGCR2/IDD

1

11

High-throughput

0.691

High

688555

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

15

High-throughput

0.691

High

688602

BT2A2
Butyrophilin subfamily 2 member A2

1

1

High-throughput

0.691

High

688603

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

7

High-throughput

0.691

High

688605

HMR1
Major histocompatibility complex class I-related protein 1

1

20

High-throughput

0.691

High

688607

SO4A1
Solute carrier organic anion transporter family member 4A1

1

4

High-throughput

0.691

High

688615

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

17

High-throughput

0.691

High

688620

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

9

High-throughput

0.691

High

688622

CNTP3
Contactin-associated protein-like 3

1

14

High-throughput

0.691

High

688636

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

20

High-throughput

0.691

High

688638

MRC2
C-type mannose receptor 2

1

17

High-throughput

0.691

High

688648

JAG2
Protein jagged-2

1

12

High-throughput

0.691

High

688549

PMP22
Peripheral myelin protein 22

3

7

High-throughput

0.675

High

688579

POTEE
POTE ankyrin domain family member E

1

4

High-throughput

0.618

High

688586

AMGO1
Amphoterin-induced protein 1

1

20

High-throughput

0.618

High

568036

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

20

Small-scale

0.618

High

636199

MAL
Myelin and lymphocyte protein

3

8

High-throughput

0.616

High

284484

CLD11
Claudin-11

2

6

High-throughput

0.606

High

328631

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.606

High

688525

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

6

High-throughput

0.606

High

688526

CD82
CD82 antigen

2

13

High-throughput

0.606

High

688529

CXB2
Gap junction beta-2 protein

2

4

High-throughput

0.606

High

688534

CD151
CD151 antigen

2

15

High-throughput

0.606

High

688540

EMP1
Epithelial membrane protein 1

2

6

High-throughput

0.606

High

688541

EMP3
Epithelial membrane protein 3

2

6

High-throughput

0.606

High

688544

MYPR
Myelin proteolipid protein

2

1

High-throughput

0.606

High

688553

MALL
MAL-like protein

2

8

High-throughput

0.606

High

688565

NKG7
Protein NKG7

2

2

High-throughput

0.606

High

688568

TTMP
TPA-induced transmembrane protein

2

1

High-throughput

0.606

High

688570

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

1

High-throughput

0.606

High

688572

TSPO2
Translocator protein 2

2

3

High-throughput

0.606

High

688616

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

6

High-throughput

0.606

High

688623

GPR61
G-protein coupled receptor 61

2

2

High-throughput

0.606

High

688633

CXB4
Gap junction beta-4 protein

2

4

High-throughput

0.606

High

688580

TM182
Transmembrane protein 182

2

0

High-throughput

0.580

High

688625

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.580

High

379884

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

20

High-throughput

0.575

High

607347

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

20

Small-scale

0.575

High

49774

CLRN2
Clarin-2

2

2

High-throughput

0.553

High

295672

UPK1B
Uroplakin-1b

2

14

High-throughput

0.553

High

327167

ZFPL1
Zinc finger protein-like 1

2

2

High-throughput

0.553

High

335537

BMP10
Bone morphogenetic protein 10

2

2

High-throughput

0.553

High

337289

CXB6
Gap junction beta-6 protein

2

4

High-throughput

0.553

High

688567

CTXN3
Cortexin-3

2

2

High-throughput

0.553

High

688578

BRID5
BRICHOS domain-containing protein 5

2

2

High-throughput

0.553

High

688581

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

1

High-throughput

0.553

High

688582

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

5

High-throughput

0.553

High

688590

LSME2
Leucine-rich single-pass membrane protein 2

2

1

High-throughput

0.553

High

688606

TMM54
Transmembrane protein 54

2

1

High-throughput

0.553

High

688617

CGRF1
Cell growth regulator with RING finger domain protein 1

2

1

High-throughput

0.553

High

688640

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

4

High-throughput

0.553

High

175324

PLXB2
Plexin-B2

1

20

High-throughput

0.536

High

247502

FZD6
Frizzled-6

1

4

High-throughput

0.536

High

249426

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.536

High

269654

PLXA2
Plexin-A2

1

18

High-throughput

0.536

High

337527

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

8

High-throughput

0.536

High

343837

SEM4F
Semaphorin-4F

1

11

High-throughput

0.536

High

565563

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

11

High-throughput

0.536

High

582371

B4GT1
Beta-1,4-galactosyltransferase 1

1

4

High-throughput

0.536

High

612038

ITB5
Integrin beta-5

1

13

High-throughput

0.536

High

688528

CALX
Calnexin

1

20

High-throughput

0.536

High

688533

GLRB
Glycine receptor subunit beta

1

3

High-throughput

0.536

High

688535

MA2A2
Alpha-mannosidase 2x

1

4

High-throughput

0.536

High

688536

DYN2
Dynamin-2

1

4

High-throughput

0.536

High

688537

PLXA3
Plexin-A3

1

17

High-throughput

0.536

High

688543

BACE1
Beta-secretase 1

1

5

High-throughput

0.536

High

688545

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

688551

TGBR3
Transforming growth factor beta receptor type 3

1

1

High-throughput

0.536

High

688552

HYAL2
Hyaluronidase-2

1

2

High-throughput

0.536

High

688557

MTR1L
Melatonin-related receptor

1

6

High-throughput

0.536

High

688558

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

6

High-throughput

0.536

High

688559

GAS6
Growth arrest-specific protein 6

1

15

High-throughput

0.536

High

688561

RB39A
Ras-related protein Rab-39A

1

9

High-throughput

0.536

High

688564

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

688583

LRP10
Low-density lipoprotein receptor-related protein 10

1

11

High-throughput

0.536

High

688584

GALT7
N-acetylgalactosaminyltransferase 7

1

14

High-throughput

0.536

High

688587

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

14

High-throughput

0.536

High

688589

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.536

High

688591

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

1

High-throughput

0.536

High

688595

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

14

High-throughput

0.536

High

688597

SPP2B
Signal peptide peptidase-like 2B

1

2

High-throughput

0.536

High

688604

SEM4D
Semaphorin-4D

1

11

High-throughput

0.536

High

688608

OTUL
Ubiquitin thioesterase otulin

1

1

High-throughput

0.536

High

688609

RB39B
Ras-related protein Rab-39B

1

9

High-throughput

0.536

High

688613

S47A1
Multidrug and toxin extrusion protein 1

1

4

High-throughput

0.536

High

688614

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

688626

SEM6A
Semaphorin-6A

1

11

High-throughput

0.536

High

688629

RN167
E3 ubiquitin-protein ligase RNF167

1

8

High-throughput

0.536

High

688630

VEZA
Vezatin

1

2

High-throughput

0.536

High

688631

PGAP6
Post-GPI attachment to proteins factor 6

1

1

High-throughput

0.536

High

688632

ABCB6
ATP-binding cassette sub-family B member 6

1

8

High-throughput

0.536

High

688644

PLXA1
Plexin-A1

1

17

High-throughput

0.536

High

688645

GRID1
Glutamate receptor ionotropic, delta-1

1

1

High-throughput

0.536

High

688647

DYN3
Dynamin-3

1

6

High-throughput

0.536

High

688653

LRP12
Low-density lipoprotein receptor-related protein 12

1

15

High-throughput

0.536

High

688654

BACE2
Beta-secretase 2

1

5

High-throughput

0.536

High

688527

CALR
Calreticulin

1

20

High-throughput

0.515

High

688651

ITM2B
Integral membrane protein 2B

1

10

High-throughput

0.515

High

688596

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

688637

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

688563

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

170666

CLGN
Calmegin

1

20

High-throughput

0.489

High

219799

CHSTA
Carbohydrate sulfotransferase 10

1

5

High-throughput

0.489

High

226471

SNG3
Synaptogyrin-3

1

1

High-throughput

0.489

High

253813

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

269990

XYLK
Glycosaminoglycan xylosylkinase

1

2

High-throughput

0.489

High

299865

C1QRF
C1q-related factor

1

8

High-throughput

0.489

High

322701

RHBT3
Rho-related BTB domain-containing protein 3

1

11

High-throughput

0.489

High

337250

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

9

High-throughput

0.489

High

344456

STR3N
STARD3 N-terminal-like protein

1

4

High-throughput

0.489

High

354910

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.489

High

618177

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

1

High-throughput

0.489

High

688531

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

5

High-throughput

0.489

High

688538

AP3M2
AP-3 complex subunit mu-2

1

3

High-throughput

0.489

High

688547

TBA1B
Tubulin alpha-1B chain

1

6

High-throughput

0.489

High

688550

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

2

High-throughput

0.489

High

688556

TBB3
Tubulin beta-3 chain

1

7

High-throughput

0.489

High

688560

STAR3
StAR-related lipid transfer protein 3

1

4

High-throughput

0.489

High

688562

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

8

High-throughput

0.489

High

688566

TBB8
Tubulin beta-8 chain

1

7

High-throughput

0.489

High

688569

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

6

High-throughput

0.489

High

688571

DIK1A
Divergent protein kinase domain 1A

1

5

High-throughput

0.489

High

688573

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.489

High

688574

HEAT6
HEAT repeat-containing protein 6

1

3

High-throughput

0.489

High

688576

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.489

High

688588

CDK20
Cyclin-dependent kinase 20

1

1

High-throughput

0.489

High

688592

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

7

High-throughput

0.489

High

688594

NETO2
Neuropilin and tolloid-like protein 2

1

8

High-throughput

0.489

High

688598

SFXN5
Sideroflexin-5

1

5

High-throughput

0.489

High

688600

PXYP1
2-phosphoxylose phosphatase 1

1

4

High-throughput

0.489

High

688601

CHPT1
Cholinephosphotransferase 1

1

2

High-throughput

0.489

High

688612

C1GLC
C1GALT1-specific chaperone 1

1

6

High-throughput

0.489

High

688618

CDC6
Cell division control protein 6 homolog

1

1

High-throughput

0.489

High

688619

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

14

High-throughput

0.489

High

688624

TM39B
Transmembrane protein 39B

1

2

High-throughput

0.489

High

688628

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

4

High-throughput

0.489

High

688634

MDN1
Midasin

1

5

High-throughput

0.489

High

688635

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

12

High-throughput

0.489

High

688639

B4GT7
Beta-1,4-galactosyltransferase 7

1

4

High-throughput

0.489

High

688641

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

1

High-throughput

0.489

High

688643

EI2BD
Translation initiation factor eIF2B subunit delta

1

4

High-throughput

0.489

High

688646

DD19B
ATP-dependent RNA helicase DDX19B

1

4

High-throughput

0.489

High

688649

CDYL
Chromodomain Y-like protein

1

2

High-throughput

0.489

High

688650

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

9

High-throughput

0.489

High

688652

AP3M1
AP-3 complex subunit mu-1

1

3

High-throughput

0.489

High

688530

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

688532

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.470

High

688599

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.470

High

97172

TM262
Cation channel sperm-associated auxiliary subunit TMEM262

2

0

High-throughput

0.316

High

547971

PSPC
Surfactant protein C

2

0

High-throughput

0.316

High

688593

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

0

High-throughput

0.316

High

66132

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.279

Low

688575

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.279

Low

688577

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.279

Low

688585

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.279

Low

688610

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.279

Low

688627

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.279

Low

343137

CXL14
C-X-C motif chemokine 14

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025