Protein: TB22B
TBC1 domain family member 22B

Gene: TB22B, TBC1D22B
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q9NU19

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005794 - Golgi apparatus
GO:0071889 - 14-3-3 protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356482

TB22A
TBC1 domain family member 22A

2

7

High-throughput

0.811

High

976596

RB11A
Ras-related protein Rab-11A

2

17

High-throughput

0.754

High

1323357

VPS52
Vacuolar protein sorting-associated protein 52 homolog

4

3

High-throughput

0.698

High

1449701

TACC3
Transforming acidic coiled-coil-containing protein 3

4

3

High-throughput

0.698

High

1432808

GCP60
Golgi resident protein GCP60

3

1

Small-scale

0.673

High

1063644

GOGA2
Golgin subfamily A member 2

3

2

High-throughput

0.671

High

783432

TRI23
E3 ubiquitin-protein ligase TRIM23

5

18

High-throughput

0.654

High

476518

STS
Steryl-sulfatase

2

2

High-throughput

0.628

High

1449682

TB22B
TBC1 domain family member 22B

1

7

High-throughput

0.621

High

374229

RASN
GTPase NRas

1

20

High-throughput

0.618

High

945107

RAB25
Ras-related protein Rab-25

1

18

High-throughput

0.618

High

975272

ARF6
ADP-ribosylation factor 6

2

12

High-throughput

0.611

High

1049829

1433F
14-3-3 protein eta

3

20

High-throughput

0.609

High

64559

CC88B
Coiled-coil domain-containing protein 88B

2

4

High-throughput

0.606

High

1415240

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.606

High

900533

FXR2
RNA-binding protein FXR2

3

1

High-throughput

0.606

High

1115619

ASPP2
Apoptosis-stimulating of p53 protein 2

3

3

High-throughput

0.606

High

1419236

TRI54
Tripartite motif-containing protein 54

3

15

High-throughput

0.606

High

1206001

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

4

High-throughput

0.593

High

1083322

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.580

High

1431870

GO45
Golgin-45

2

0

High-throughput

0.580

High

1448362

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

210792

KLK10
Kallikrein-10

2

4

High-throughput

0.574

High

248791

PEPL
Periplakin

2

6

High-throughput

0.574

High

261663

CATL2
Cathepsin L2

2

3

High-throughput

0.574

High

276637

LX12B
Arachidonate 12-lipoxygenase, 12R-type

2

1

High-throughput

0.574

High

289285

SPB7
Serpin B7

2

7

High-throughput

0.574

High

369511

AACT
Alpha-1-antichymotrypsin

2

6

High-throughput

0.574

High

424275

S10A8
Protein S100-A8

2

5

High-throughput

0.574

High

445078

S10A9
Protein S100-A9

2

7

High-throughput

0.574

High

457135

CAN1
Calpain-1 catalytic subunit

2

7

High-throughput

0.574

High

457924

INVO
Involucrin

2

1

High-throughput

0.574

High

485822

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

2

3

High-throughput

0.574

High

615241

IL1RA
Interleukin-1 receptor antagonist protein

2

1

High-throughput

0.574

High

652423

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.574

High

671866

ZA2G
Zinc-alpha-2-glycoprotein

2

1

High-throughput

0.574

High

682628

S100P
Protein S100-P

2

8

High-throughput

0.574

High

713466

SPB3
Serpin B3

2

7

High-throughput

0.574

High

721532

ILEU
Leukocyte elastase inhibitor

2

7

High-throughput

0.574

High

724641

S10A7
Protein S100-A7

2

7

High-throughput

0.574

High

729623

CASPE
Caspase-14

2

1

High-throughput

0.574

High

787715

SPB5
Serpin B5

2

7

High-throughput

0.574

High

818770

CAPG
Macrophage-capping protein

2

2

High-throughput

0.574

High

827940

STAT3
Signal transducer and activator of transcription 3

2

1

High-throughput

0.574

High

868776

LEG7
Galectin-7

2

2

High-throughput

0.574

High

874876

SPB4
Serpin B4

2

7

High-throughput

0.574

High

892140

KLK7
Kallikrein-7

2

3

High-throughput

0.574

High

895470

SPB8
Serpin B8

2

7

High-throughput

0.574

High

932351

ARSF
Arylsulfatase F

2

2

High-throughput

0.574

High

945870

EPIPL
Epiplakin

2

7

High-throughput

0.574

High

966928

1433G
14-3-3 protein gamma

2

20

High-throughput

0.574

High

1036807

DSG1
Desmoglein-1

2

6

High-throughput

0.574

High

1062303

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

2

High-throughput

0.574

High

1120973

TRI29
Tripartite motif-containing protein 29

2

6

High-throughput

0.574

High

1153706

CH3L2
Chitinase-3-like protein 2

2

1

High-throughput

0.574

High

1187263

PA24E
Cytosolic phospholipase A2 epsilon

2

1

High-throughput

0.574

High

1286356

S1A7A
Protein S100-A7A

2

7

High-throughput

0.574

High

1330750

SIGL1
SIGLEC family-like protein 1

2

1

High-throughput

0.574

High

1338074

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

1

High-throughput

0.574

High

1352133

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

2

3

High-throughput

0.574

High

1369018

EVPL
Envoplakin

2

7

High-throughput

0.574

High

1390845

S10AG
Protein S100-A16

2

8

High-throughput

0.574

High

1396692

CPNS2
Calpain small subunit 2

2

9

High-throughput

0.574

High

1449687

CALL5
Calmodulin-like protein 5

2

8

High-throughput

0.574

High

1449689

I36RA
Interleukin-36 receptor antagonist protein

2

1

High-throughput

0.574

High

1449690

CBPA4
Carboxypeptidase A4

2

1

High-throughput

0.574

High

1449691

SPB13
Serpin B13

2

7

High-throughput

0.574

High

1449692

CLC4K
C-type lectin domain family 4 member K

2

2

High-throughput

0.574

High

1449698

NEUR2
Sialidase-2

2

1

High-throughput

0.574

High

250345

VINEX
Vinexin

2

1

High-throughput

0.573

High

572238

TRI27
Zinc finger protein RFP

2

4

High-throughput

0.573

High

1053436

DEUP1
Deuterosome assembly protein 1

2

6

High-throughput

0.573

High

1230278

K1C40
Keratin, type I cytoskeletal 40

2

4

High-throughput

0.573

High

1400228

PNMA5
Paraneoplastic antigen-like protein 5

2

1

High-throughput

0.573

High

300510

KRT34
Keratin, type I cuticular Ha4

2

4

High-throughput

0.553

High

570612

GFAP
Glial fibrillary acidic protein

2

6

High-throughput

0.553

High

870171

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

2

2

High-throughput

0.553

High

900190

FXR1
RNA-binding protein FXR1

2

1

High-throughput

0.553

High

1049022

REL
Proto-oncogene c-Rel

2

1

High-throughput

0.553

High

1116602

FHL3
Four and a half LIM domains protein 3

2

2

High-throughput

0.553

High

1151666

TRIP6
Thyroid receptor-interacting protein 6

2

3

High-throughput

0.553

High

1206440

EFHC2
EF-hand domain-containing family member C2

2

8

High-throughput

0.553

High

1229376

LHX8
LIM/homeobox protein Lhx8

2

2

High-throughput

0.553

High

1332656

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

2

High-throughput

0.553

High

1388868

HOOK2
Protein Hook homolog 2

2

3

High-throughput

0.553

High

1398373

CEP63
Centrosomal protein of 63 kDa

2

5

High-throughput

0.553

High

1398721

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.553

High

1416375

CAR10
Caspase recruitment domain-containing protein 10

2

4

High-throughput

0.553

High

1445892

HM20A
High mobility group protein 20A

2

1

High-throughput

0.553

High

1449315

HOME3
Homer protein homolog 3

2

3

High-throughput

0.553

High

1449693

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

19

High-throughput

0.553

High

630992

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.553

High

631508

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.553

High

902100

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.553

High

1209711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.536

High

1334585

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

75732

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

2

1

High-throughput

0.533

High

540701

LAMP1
Lysosome-associated membrane glycoprotein 1

2

8

High-throughput

0.533

High

1095817

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

8

High-throughput

0.523

High

1180032

CCD57
Coiled-coil domain-containing protein 57

1

1

High-throughput

0.523

High

1307804

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.523

High

69559

A2ML1
Alpha-2-macroglobulin-like protein 1

2

1

High-throughput

0.504

High

379141

IGKC
Immunoglobulin kappa constant

2

4

High-throughput

0.504

High

920512

DAPK1
Death-associated protein kinase 1

1

2

High-throughput

0.489

High

1449699

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

3

High-throughput

0.489

High

388311

GLPA
Glycophorin-A

1

2

High-throughput

0.489

High

486628

TACD2
Tumor-associated calcium signal transducer 2

1

5

High-throughput

0.489

High

568983

ANXA8
Annexin A8

1

1

High-throughput

0.489

High

572336

CBPM
Carboxypeptidase M

1

1

High-throughput

0.489

High

587820

DESP
Desmoplakin

1

7

High-throughput

0.489

High

635643

FILA
Filaggrin

1

5

High-throughput

0.489

High

730284

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

972051

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.489

High

990785

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.489

High

1116191

FCL
GDP-L-fucose synthase

1

1

High-throughput

0.489

High

1153445

CD226
CD226 antigen

1

6

High-throughput

0.489

High

1204037

FILA2
Filaggrin-2

1

4

High-throughput

0.489

High

1294073

PA24D
Cytosolic phospholipase A2 delta

1

1

High-throughput

0.489

High

1359937

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

High-throughput

0.489

High

1418698

LOXE3
Hydroperoxide isomerase ALOXE3

1

1

High-throughput

0.489

High

1449684

ARL8B
ADP-ribosylation factor-like protein 8B

1

20

High-throughput

0.489

High

218831

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

226224

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

327469

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

604234

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

1015136

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.479

High

1041321

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

47279

A0A6Q8KRG2
Golgin subfamily A member 2

1

3

High-throughput

0.457

High

1449702

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

2

Small-scale

0.445

High

180065

BET1
BET1 homolog

1

4

High-throughput

0.437

High

189872

STX7
Syntaxin-7

1

5

High-throughput

0.437

High

541709

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.437

High

556370

CADH1
Cadherin-1

1

4

High-throughput

0.437

High

562437

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.437

High

710518

EPHA2
Ephrin type-A receptor 2

1

12

High-throughput

0.437

High

931904

EPHA5
Ephrin type-A receptor 5

1

12

High-throughput

0.437

High

958823

ARF3
ADP-ribosylation factor 3

1

10

High-throughput

0.437

High

986757

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.437

High

1014969

ARF1
ADP-ribosylation factor 1

1

10

High-throughput

0.437

High

1229103

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.437

High

1233520

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

1293172

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1323014

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.437

High

1449696

LAMP3
Lysosome-associated membrane glycoprotein 3

1

8

High-throughput

0.437

High

379316

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.407

High

379404

IGHG2
Immunoglobulin heavy constant gamma 2

1

3

High-throughput

0.407

High

640304

EPHA1
Ephrin type-A receptor 1

1

9

High-throughput

0.407

High

754112

CD80
T-lymphocyte activation antigen CD80

1

5

High-throughput

0.407

High

1293915

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.407

High

1371726

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.407

High

1449694

IKZF3
Zinc finger protein Aiolos

5

0

High-throughput

0.373

High

1409648

DHB14
L-fucose dehydrogenase

4

0

High-throughput

0.364

High

126260

ST2B1
Sulfotransferase 2B1

2

0

High-throughput

0.328

High

238680

AK1BA
Aldo-keto reductase family 1 member B10

2

0

High-throughput

0.328

High

483972

HMOX1
Heme oxygenase 1

2

0

High-throughput

0.328

High

578724

GLNA
Glutamine synthetase

2

0

High-throughput

0.328

High

582628

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.328

High

609339

SAP3
Ganglioside GM2 activator

2

0

High-throughput

0.328

High

627169

TYPH
Thymidine phosphorylase

2

0

High-throughput

0.328

High

839633

HUTH
Histidine ammonia-lyase

2

0

High-throughput

0.328

High

1009732

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.328

High

1159423

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.328

High

1242368

PLBL1
Phospholipase B-like 1

2

0

High-throughput

0.328

High

1248744

SBSN
Suprabasin

2

0

High-throughput

0.328

High

1292007

NAL10
NACHT, LRR and PYD domains-containing protein 10

2

0

High-throughput

0.328

High

1325565

RDHE2
Epidermal retinol dehydrogenase 2

2

0

High-throughput

0.328

High

1358587

POF1B
Protein POF1B

2

0

High-throughput

0.328

High

1400658

GSDMA
Gasdermin-A

2

0

High-throughput

0.328

High

1430259

5NT3A
Cytosolic 5'-nucleotidase 3A

2

0

High-throughput

0.328

High

1449700

CRBG1
Beta/gamma crystallin domain-containing protein 1

2

0

High-throughput

0.328

High

1033433

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.327

High

213377

ARHG9
Rho guanine nucleotide exchange factor 9

2

0

High-throughput

0.316

High

783759

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

1201902

PKHG4
Puratrophin-1

2

0

High-throughput

0.316

High

1209166

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

1278743

ZN438
Zinc finger protein 438

2

0

High-throughput

0.316

High

1315138

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1336406

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.316

High

1340365

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1353575

ZFP90
Zinc finger protein 90 homolog

2

0

High-throughput

0.316

High

1386894

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1449695

SPAT2
Spermatogenesis-associated protein 2

2

0

High-throughput

0.316

High

1449697

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1023187

RBM10
RNA-binding protein 10

1

0

High-throughput

0.299

High

1314998

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.299

High

168151

FSCN2
Fascin-2

1

0

High-throughput

0.279

Low

328452

SCEL
Sciellin

1

0

High-throughput

0.279

Low

1108813

ASAH1
Acid ceramidase

1

0

High-throughput

0.279

Low

1154353

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1256996

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1272467

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

1431047

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

1449685

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.279

Low

140005

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

1436333

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1449683

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1449686

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1449688

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1099796

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.232

Low

1199952

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025