HitPredict

Interactor 1: SI1L2 (Q9P2F8)
Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)
Gene: SIPA1L2

Interactor 2: LZTS1 (Q9Y250)
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Gene: LZTS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1722 Hs			1 596
+	Hs
		1310197 SI1L2_HUMAN (1-1722): 0: 1821: 100.00		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		230555 SI1L2_HUMAN (1-1722): 0: 1821: 100.00		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		165788 SI1L2_HUMAN (1-1722): 0: 1821: 100.00		N4BP3_HUMAN (1-576): 8.13e-35: 140: 27.24
+	Hs
		1145965 SI1L2_HUMAN (1-1722): 0: 1821: 100.00		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		196501 SI1L1_HUMAN (1-1719): 0: 1424: 48.02		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		196381 SI1L1_HUMAN (1-1719): 0: 1424: 48.02		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		196455 SI1L1_HUMAN (1-1719): 0: 1424: 48.02		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		230273 SI1L3_HUMAN (19-1714): 0: 1313: 42.85		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		230186 SI1L3_HUMAN (19-1714): 0: 1313: 42.85		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		230265 SI1L3_HUMAN (19-1714): 0: 1313: 42.85		MY18A_HUMAN (240-536): 3.63e-11: 68.5: 12.58
+	Hs
		230253 SI1L3_HUMAN (19-1714): 0: 1313: 42.85		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		230212 SI1L3_HUMAN (19-1714): 0: 1313: 42.85		MYH9_HUMAN (154-534): 4.65e-10: 64.9: 12.04
+	Hs
		835090 TSC2_HUMAN (538-860): 1.95e-102: 367: 21.07		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Mm
		1142070 TSC2_MOUSE (538-860): 4.04e-102: 365: 19.65		TSC1_MOUSE (12-571): 6.3e-33: 137: 12.96
+	Rn
		835139 TSC2_RAT (538-860): 7.73e-102: 365: 19.10		TSC1_RAT (11-555): 3.04e-32: 135: 10.94
+	Mm
		1112023 Q3TQ10_MOUSE (639-860): 2.1e-78: 261: 18.57		TSC1_MOUSE (12-571): 6.3e-33: 137: 12.96
+	Hs
		1291406 SIPA1_HUMAN (1389-1707): 1.51e-20: 101: 18.71		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		1068686 RHG23_HUMAN (960-1528): 4.6e-39: 162: 13.57		PLEC_HUMAN (278-582): 2.47e-10: 66.1: 17.50
+	Hs
		724961 SIPA1_HUMAN (1389-1707): 1.51e-20: 101: 18.71		MYH9_HUMAN (154-534): 4.65e-10: 64.9: 12.04