Protein: FCGRN
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)

Gene: FCGRN, FCGRT
Organism: Homo sapiens
Interactions: 115
UniProt ID: P55899

Gene Ontology (top 5):
GO:0002416 - IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO:0005615 - extracellular space
GO:0006955 - immune response
GO:0009897 - external side of plasma membrane
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

939483

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

4

20

Small-scale

0.899

High

705950

CD1B
T-cell surface glycoprotein CD1b

3

17

High-throughput

0.861

High

369252

ANT3
Antithrombin-III

2

3

High-throughput

0.811

High

586174

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

2

17

High-throughput

0.811

High

939487

HGFA
Hepatocyte growth factor activator serine protease

2

10

High-throughput

0.811

High

939499

PRTG
Protogenin

2

4

High-throughput

0.811

High

939528

ULBP3
UL16-binding protein 3

2

16

High-throughput

0.811

High

939534

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.811

High

389999

ALBU
Albumin

2

1

Small-scale

0.806

High

568050

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

17

High-throughput

0.789

High

333452

MPZL1
Myelin protein zero-like protein 1

2

2

High-throughput

0.726

High

541416

FGFR1
Fibroblast growth factor receptor 1

2

16

High-throughput

0.726

High

641146

FGFR2
Fibroblast growth factor receptor 2

2

19

High-throughput

0.726

High

648473

FGFR4
Fibroblast growth factor receptor 4

2

16

High-throughput

0.726

High

939491

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

5

High-throughput

0.726

High

688542

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

High-throughput

0.691

High

939500

HFE
Hereditary hemochromatosis protein

1

16

High-throughput

0.691

High

939529

ULBP2
UL16-binding protein 2

1

16

High-throughput

0.691

High

939530

RTN4R
Reticulon-4 receptor

1

2

High-throughput

0.691

High

136488

GOLI4
Golgi integral membrane protein 4

2

2

High-throughput

0.628

High

376489

LDLR
Low-density lipoprotein receptor

2

5

High-throughput

0.628

High

464432

TSP1
Thrombospondin-1

2

1

High-throughput

0.628

High

488758

FURIN
Furin

2

4

High-throughput

0.628

High

834655

TNFL9
Tumor necrosis factor ligand superfamily member 9

2

2

High-throughput

0.628

High

939485

HBA
Hemoglobin subunit alpha

2

1

High-throughput

0.628

High

939548

ITM2B
Integral membrane protein 2B

2

6

High-throughput

0.628

High

522624

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

5

High-throughput

0.618

High

939490

CNTN1
Contactin-1

1

2

High-throughput

0.618

High

939516

FAM3C
Protein FAM3C

2

4

High-throughput

0.606

High

649179

GALA
Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide

2

0

High-throughput

0.602

High

469419

ELNE
Neutrophil elastase

1

14

Small-scale

0.590

High

409329

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

16

High-throughput

0.575

High

212061

B4GT5
Beta-1,4-galactosyltransferase 5

2

1

High-throughput

0.574

High

220121

SGCE
Epsilon-sarcoglycan

2

1

High-throughput

0.574

High

270545

LRP4
Low-density lipoprotein receptor-related protein 4

2

5

High-throughput

0.574

High

274864

LRP5
Low-density lipoprotein receptor-related protein 5

2

5

High-throughput

0.574

High

939488

APLP2
Amyloid beta precursor like protein 2

2

1

High-throughput

0.574

High

939497

KIF14
Kinesin-like protein KIF14

2

3

High-throughput

0.574

High

939523

DUS9
Dual specificity protein phosphatase 9

2

1

High-throughput

0.574

High

939539

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

1

High-throughput

0.574

High

939542

PDXL2
Podocalyxin-like protein 2

2

1

High-throughput

0.574

High

939544

PCD10
Protocadherin-10

2

5

High-throughput

0.574

High

939553

PCDGB
Protocadherin gamma-A11

2

3

High-throughput

0.574

High

939554

TNPO3
Transportin-3

2

4

High-throughput

0.574

High

164556

TNPO2
Transportin-2

2

1

High-throughput

0.558

High

939545

AT1B4
Protein ATP1B4

2

3

High-throughput

0.558

High

139200

UPK2
Uroplakin-2

2

3

High-throughput

0.553

High

939486

PMP22
Peripheral myelin protein 22

2

1

High-throughput

0.553

High

939543

NINJ2
Ninjurin-2

2

1

High-throughput

0.553

High

249593

SNX3
Sorting nexin-3

1

2

High-throughput

0.536

High

351677

SG1D1
Secretoglobin family 1D member 1

1

1

High-throughput

0.536

High

252383

GFRA3
GDNF family receptor alpha-3

1

0

High-throughput

0.513

High

533629

CLUS
Clusterin

1

0

High-throughput

0.513

High

161128

ABCD4
Lysosomal cobalamin transporter ABCD4

1

7

High-throughput

0.489

High

167739

PCD17
Protocadherin-17

1

5

High-throughput

0.489

High

239782

PCDH7
Protocadherin-7

1

7

High-throughput

0.489

High

287542

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

High-throughput

0.489

High

293438

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.489

High

853206

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.489

High

939489

PCDH1
Protocadherin-1

1

7

High-throughput

0.489

High

939492

KLF5
Krueppel-like factor 5

1

1

High-throughput

0.489

High

939493

DSC3
Desmocollin-3

1

3

High-throughput

0.489

High

939495

CND1
Condensin complex subunit 1

1

1

High-throughput

0.489

High

939501

CC50B
Cell cycle control protein 50B

1

6

High-throughput

0.489

High

939502

LARP7
La-related protein 7

1

1

High-throughput

0.489

High

939510

SE6L2
Seizure 6-like protein 2

1

1

High-throughput

0.489

High

939515

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

1

High-throughput

0.489

High

939519

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

939538

STK36
Serine/threonine-protein kinase 36

1

1

High-throughput

0.489

High

939541

S39A1
Zinc transporter ZIP1

1

14

High-throughput

0.489

High

939552

SBDS
Ribosome maturation protein SBDS

1

1

High-throughput

0.489

High

838037

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.470

High

48233

TM129
E3 ubiquitin-protein ligase TM129

1

1

Small-scale

0.437

High

630743

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.437

High

939484

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.437

High

939507

A16L1
Autophagy-related protein 16-1

1

4

Small-scale

0.437

High

939511

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

Small-scale

0.437

High

939527

DERL1
Derlin-1

1

2

Small-scale

0.437

High

939537

A4GAT
Lactosylceramide 4-alpha-galactosyltransferase

1

2

High-throughput

0.437

High

939503

Q4LE60
TNPO2 variant protein

1

1

High-throughput

0.407

High

939496

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

0

High-throughput

0.328

High

939504

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.328

High

939505

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

2

0

High-throughput

0.328

High

939513

DYHC2
Cytoplasmic dynein 2 heavy chain 1

2

0

High-throughput

0.328

High

939522

XPO6
Exportin-6

2

0

High-throughput

0.328

High

939546

TIM
Protein timeless homolog

2

0

High-throughput

0.328

High

939547

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.328

High

939550

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

939551

SHLB1
Endophilin-B1

2

0

High-throughput

0.328

High

939512

CLD19
Claudin-19

2

0

High-throughput

0.316

High

282984

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.279

Low

286439

WBP4
WW domain-binding protein 4

1

0

High-throughput

0.279

Low

339332

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.279

Low

479355

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.279

Low

708884

T2EA
General transcription factor IIE subunit 1

1

0

High-throughput

0.279

Low

939494

MESD
LRP chaperone MESD

1

0

High-throughput

0.279

Low

939498

SURF2
Surfeit locus protein 2

1

0

High-throughput

0.279

Low

939508

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

939509

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.279

Low

939514

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.279

Low

939517

ELP4
Elongator complex protein 4

1

0

High-throughput

0.279

Low

939518

KBP
KIF-binding protein

1

0

High-throughput

0.279

Low

939520

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.279

Low

939521

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.279

Low

939524

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.279

Low

939525

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

939526

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.279

Low

939531

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.279

Low

939532

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.279

Low

939533

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

0

High-throughput

0.279

Low

939535

HES4
Transcription factor HES-4

1

0

High-throughput

0.279

Low

939536

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.279

Low

939540

TXN4B
Thioredoxin-like protein 4B

1

0

High-throughput

0.279

Low

939549

EXC6B
Exocyst complex component 6B

1

0

High-throughput

0.279

Low

939506

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025