HitPredict

Interactor 1: NDKM (O00746)
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)
Gene: NME4

Interactor 2: NDKA (P15531)
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)
Gene: NME1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.954

Property	Details
Experiments	32296183, 25416956, 16189514, 33961781, 31515488, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	NDK~NDK
Common GO terms	GO:0004550 - nucleoside diphosphate kinase activity GO:0005524 - ATP binding GO:0006183 - GTP biosynthetic process GO:0006228 - UTP biosynthetic process GO:0006241 - CTP biosynthetic process and 1 others more... GO:0016310 - phosphorylation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 187 Hs			1 152
+	Hs
		135574 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDKB_HUMAN (1-152): 4.45e-92: 265: 88.16
+	Hs
		135616 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDK3_HUMAN (5-152): 3.29e-83: 243: 67.57
+	Hs
		607586 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDKB_HUMAN (1-152): 4.45e-92: 265: 88.16
+	Hs
		548860 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDKA_HUMAN (1-152): 2.55e-91: 263: 100.00
+	Hs
		548853 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDKA_HUMAN (1-152): 2.55e-91: 263: 100.00
+	Hs
		135540 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDKM_HUMAN (5-148): 5.93e-76: 225: 58.33
+	Hs
		607647 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDK3_HUMAN (5-152): 3.29e-83: 243: 67.57
+	Dm
		65459 A8E6J4_DROME (21-185): 1.46e-83: 246: 49.40		NDKA_DROME (2-152): 2.5e-86: 250: 77.48
+	Dm
		445605 NDKA_DROME (34-185): 4.3e-83: 244: 52.63		NDKA_DROME (2-152): 2.5e-86: 250: 77.48
+	Hs
		548904 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDK3_HUMAN (5-152): 3.29e-83: 243: 67.57
+	Hs
		233739 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDK8_HUMAN (16-152): 1.39e-77: 228: 84.67
+	Ce
		1274720 Q93576_CAEEL (34-185): 7.75e-82: 241: 51.32		Q93576_CAEEL (1-152): 2.15e-82: 240: 67.32
+	Hs
		233736 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDK8_HUMAN (16-152): 1.39e-77: 228: 84.67
+	At
		249500 NDK2_ARATH (4-184): 7.74e-81: 241: 44.75		NDK2_ARATH (1-152): 2.22e-79: 236: 53.95
+	Hs
		607668 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		Q32Q12_HUMAN (1-114): 1.44e-62: 195: 100.00
+	Hs
		548912 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		Q32Q12_HUMAN (1-114): 1.44e-62: 195: 100.00
+	Hs
		135725 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDK7_HUMAN (7-135): 2.35e-39: 138: 28.57