HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: RN216 (Q9NWF9)
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
Gene: RNF216

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15107846
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 179 Hs			1 866
+	Hs
		1347205 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		RN216_HUMAN (1-866): 0: 1150: 100.00
+	Hs
		919878 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RN216_HUMAN (1-866): 0: 1150: 100.00
+	Hs
		849460 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		RN216_HUMAN (1-866): 0: 1150: 100.00
+	Hs
		849498 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94
+	Hs
		312553 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		312679 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		312520 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		312645 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45
+	Hs
		1290106 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		919819 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		849403 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		1290028 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		RNF31_HUMAN (464-792): 1.29e-65: 240: 15.56
+	Hs
		1354303 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		919891 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		849474 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		1297375 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		RNF14_HUMAN (477-739): 3.6e-61: 216: 17.55
+	Hs
		919876 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RN19A_HUMAN (507-744): 5.63e-57: 212: 23.83
+	Hs
		842104 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		R144A_HUMAN (512-738): 1.87e-58: 203: 24.47
+	Hs
		919757 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RN19B_HUMAN (502-744): 4.49e-54: 202: 23.19
+	Hs
		842095 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		R144A_HUMAN (512-738): 1.87e-58: 203: 24.47