Protein: PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)

Gene: PK3C3, PIK3C3
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q8NEB9

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000425 - pexophagy
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1337311

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

12

8

Small-scale

0.978

High

631354

RAB5A
Ras-related protein Rab-5A

3

15

Small-scale

0.827

High

1126723

BECN1
Beclin-1

64

6

Small-scale

0.772

High

1252897

BAKOR
Beclin 1-associated autophagy-related key regulator

32

1

Small-scale

0.769

High

1337322

UVRAG
UV radiation resistance-associated gene protein

16

1

Small-scale

0.763

High

1337299

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

9

1

Small-scale

0.756

High

992864

RACK1
Small ribosomal subunit protein RACK1

2

4

Small-scale

0.754

High

1337314

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

4

Small-scale

0.754

High

1337304

NRBF2
Nuclear receptor-binding factor 2

8

1

Small-scale

0.754

High

966636

1433G
14-3-3 protein gamma

5

20

High-throughput

0.714

High

1337323

ZRAN1
Ubiquitin thioesterase ZRANB1

3

3

Small-scale

0.670

High

1292785

SKAP1
Src kinase-associated phosphoprotein 1

3

12

High-throughput

0.667

High

1337316

PACER
Protein associated with UVRAG as autophagy enhancer

2

1

High-throughput

0.628

High

630890

RAB4A
Ras-related protein Rab-4A

1

16

High-throughput

0.618

High

839321

MTOR
Serine/threonine-protein kinase mTOR

1

6

Small-scale

0.618

High

901949

RAB9A
Ras-related protein Rab-9A

1

19

High-throughput

0.618

High

962282

RHOA
Transforming protein RhoA

1

19

High-throughput

0.618

High

1133949

RB39A
Ras-related protein Rab-39A

1

12

Small-scale

0.618

High

1227083

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.618

High

868740

LEG7
Galectin-7

2

1

High-throughput

0.611

High

907502

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

3

Small-scale

0.611

High

1049576

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

242323

PRKN
E3 ubiquitin-protein ligase parkin

2

4

Small-scale

0.584

High

1100143

TIF1B
Transcription intermediary factor 1-beta

2

1

Small-scale

0.584

High

1337327

KLH20
Kelch-like protein 20

1

2

Small-scale

0.578

High

1337319

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

1337296

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

10

High-throughput

0.575

High

193599

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

3

Small-scale

0.561

High

1232971

OTU7B
OTU domain-containing protein 7B

1

2

Small-scale

0.561

High

1235300

STYK1
Tyrosine-protein kinase STYK1

1

11

Small-scale

0.561

High

341107

DIRA3
GTP-binding protein Di-Ras3

1

11

Small-scale

0.553

High

271548

ATG13
Autophagy-related protein 13

2

0

Small-scale

0.547

High

1337306

FXL20
F-box/LRR-repeat protein 20

1

0

Small-scale

0.537

High

388253

GLPA
Glycophorin-A

1

2

High-throughput

0.536

High

625505

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

867283

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

997871

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

1337301

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

1337313

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

2

High-throughput

0.536

High

1147542

UBE3C
Ubiquitin-protein ligase E3C

1

2

Small-scale

0.528

High

1337307

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.513

High

691260

1433T
14-3-3 protein theta

1

20

Small-scale

0.501

High

1132395

CASP8
Caspase-8

1

1

Small-scale

0.501

High

1337328

SHLB1
Endophilin-B1

1

6

Small-scale

0.500

High

1101286

SLAF1
Signaling lymphocytic activation molecule

1

5

Small-scale

0.489

High

130175

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

139134

KRIT1
Krev interaction trapped protein 1

1

2

Small-scale

0.479

High

162635

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.479

High

218495

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

246058

KIF1B
Kinesin-like protein KIF1B

1

7

Small-scale

0.479

High

258309

TRI13
E3 ubiquitin-protein ligase TRIM13

1

2

Small-scale

0.479

High

322973

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

Small-scale

0.479

High

327364

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

365427

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.479

High

412279

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

414243

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

461720

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.479

High

483370

CLCB
Clathrin light chain B

1

3

High-throughput

0.479

High

535307

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.479

High

556867

MYH1
Myosin-1

1

4

Small-scale

0.479

High

562237

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

604106

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

772910

MYH9
Myosin-9

1

5

Small-scale

0.479

High

990515

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1121465

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.479

High

1139178

JOS1
Josephin-1

1

2

Small-scale

0.479

High

1160689

DREB
Drebrin

1

4

Small-scale

0.479

High

1233361

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1254706

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1337297

JOS2
Josephin-2

1

2

Small-scale

0.479

High

1337298

TSC1
Hamartin

1

11

Small-scale

0.479

High

1337302

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

1337303

OPTN
Optineurin

1

9

High-throughput

0.479

High

1337309

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

1

Small-scale

0.479

High

1337310

RING2
E3 ubiquitin-protein ligase RING2

1

5

Small-scale

0.479

High

1337315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

1337318

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1337320

ETAA1
Ewing's tumor-associated antigen 1

1

1

High-throughput

0.479

High

1337325

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.479

High

1337326

UBP18
Ubl carboxyl-terminal hydrolase 18

1

1

Small-scale

0.479

High

332765

EPM2A
Laforin

1

0

Small-scale

0.458

High

933691

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

1134994

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1252340

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1289008

NLRX1
NLR family member X1

1

0

Small-scale

0.458

High

1315100

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.458

High

1337308

EXOC2
Exocyst complex component 2

1

0

Small-scale

0.458

High

1337312

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.458

High

1337321

DACT1
Dapper homolog 1

1

0

Small-scale

0.458

High

71497

BECN2
Beclin-2

1

6

Small-scale

0.445

High

730066

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

801419

HSPA9
Stress-70 protein, mitochondrial

1

4

Small-scale

0.445

High

886106

CXCR3
C-X-C chemokine receptor type 3

1

10

High-throughput

0.445

High

1337300

LPAR1
Lysophosphatidic acid receptor 1

1

9

High-throughput

0.445

High

106304

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

589193

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695976

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

768676

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1337324

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

239139

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.426

High

1337305

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.426

High

1219519

ANR22
Ankyrin repeat domain-containing protein 22

1

1

High-throughput

0.407

High

1258511

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

438941

CD5
T-cell surface glycoprotein CD5

1

1

Small-scale

0.348

High

1337317

JADE2
E3 ubiquitin-protein ligase Jade-2

3

0

High-throughput

0.347

High

455828

H10
Histone H1.0

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025