Protein: Q4LE69
Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67)

Gene: Q4LE69, PIK4CA
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q4LE69

Gene Ontology (top 5):
GO:0016301 - kinase activity
GO:0046854 - phosphatidylinositol phosphate biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1195660

TTC7B
Tetratricopeptide repeat protein 7B

2

5

High-throughput

0.754

High

375573

RASK
GTPase KRas

3

20

High-throughput

0.739

High

440100

LCK
Tyrosine-protein kinase Lck

2

7

Small-scale

0.687

High

374648

RASH
GTPase HRas

2

20

High-throughput

0.675

High

978050

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.675

High

1029603

CD83
CD83 antigen

2

1

High-throughput

0.675

High

1195704

PD1L1
Programmed cell death 1 ligand 1

2

2

Small-scale

0.675

High

463556

LYN
Tyrosine-protein kinase Lyn

1

8

High-throughput

0.618

High

1195712

TTC7A
Tetratricopeptide repeat protein 7A

1

3

High-throughput

0.618

High

218261

TGON2
Trans-Golgi network integral membrane protein 2

3

7

High-throughput

0.585

High

1195713

CAH14
Carbonic anhydrase 14

3

2

High-throughput

0.585

High

1195688

HYCCI
Hyccin

2

3

High-throughput

0.584

High

1195703

STRN4
Striatin-4

1

4

High-throughput

0.555

High

126630

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.553

High

373967

RASN
GTPase NRas

1

20

High-throughput

0.553

High

466292

RHOC
Rho-related GTP-binding protein RhoC

1

16

High-throughput

0.553

High

581088

RAC2
Ras-related C3 botulinum toxin substrate 2

1

17

High-throughput

0.553

High

593846

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

3

High-throughput

0.553

High

601315

RHOQ
Rho-related GTP-binding protein RhoQ

1

19

High-throughput

0.553

High

731358

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.553

High

821720

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

1

High-throughput

0.553

High

873467

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

3

High-throughput

0.553

High

901277

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.553

High

901847

RAB9A
Ras-related protein Rab-9A

1

18

High-throughput

0.553

High

910081

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.553

High

953481

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.553

High

955244

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.553

High

956323

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.553

High

962117

RHOA
Transforming protein RhoA

1

18

High-throughput

0.553

High

962757

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.553

High

976306

RB11A
Ras-related protein Rab-11A

1

10

High-throughput

0.553

High

988413

RAC1
Ras-related C3 botulinum toxin substrate 1

1

18

High-throughput

0.553

High

1015487

RHOG
Rho-related GTP-binding protein RhoG

1

17

High-throughput

0.553

High

1105948

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.553

High

1144933

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.553

High

1151719

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.553

High

1153391

CD226
CD226 antigen

1

2

High-throughput

0.553

High

1195645

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.553

High

1195658

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.553

High

1195667

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.553

High

1195679

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1195686

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.553

High

1195694

RHOJ
Rho-related GTP-binding protein RhoJ

1

19

High-throughput

0.553

High

1195700

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.553

High

1195714

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.553

High

1195718

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.553

High

520870

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

2

High-throughput

0.533

High

630161

ACM3
Muscarinic acetylcholine receptor M3

2

4

High-throughput

0.533

High

770860

OPRM
Mu-type opioid receptor

2

7

High-throughput

0.533

High

879786

NPY2R
Neuropeptide Y receptor type 2

2

7

High-throughput

0.533

High

975067

ARF6
ADP-ribosylation factor 6

2

2

High-throughput

0.533

High

1114864

CUL4A
Cullin-4A

2

1

High-throughput

0.533

High

1195669

F174A
Membrane protein FAM174A

2

1

High-throughput

0.533

High

1122012

EFR3A
Protein EFR3 homolog A

1

6

High-throughput

0.479

High

1195663

HYCC2
Hyccin 2

1

3

High-throughput

0.479

High

1195715

EFR3B
Protein EFR3 homolog B

1

6

High-throughput

0.479

High

880925

MTR1B
Melatonin receptor type 1B

1

7

High-throughput

0.457

High

1195719

SNX9
Sorting nexin-9

1

1

Small-scale

0.457

High

568562

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.439

High

1195697

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.439

High

1195699

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.439

High

50570

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.437

High

75677

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

3

High-throughput

0.437

High

106048

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

130120

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

133255

P2Y10
Putative P2Y purinoceptor 10

1

19

High-throughput

0.437

High

139885

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

182554

GP182
G-protein coupled receptor 182

1

13

High-throughput

0.437

High

189601

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

247946

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

250641

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.437

High

289258

SPB7
Serpin B7

1

11

High-throughput

0.437

High

296780

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.437

High

299224

FLOT1
Flotillin-1

1

3

High-throughput

0.437

High

303137

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.437

High

326710

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.437

High

327287

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

345902

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.437

High

351901

S1PR4
Sphingosine 1-phosphate receptor 4

1

10

High-throughput

0.437

High

372193

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

384680

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.437

High

389411

FINC
Fibronectin

1

1

High-throughput

0.437

High

396243

ESR1
Estrogen receptor

1

9

High-throughput

0.437

High

412037

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.437

High

424511

PAI2
Plasminogen activator inhibitor 2

1

8

High-throughput

0.437

High

444995

S10A9
Protein S100-A9

1

8

High-throughput

0.437

High

457869

INVO
Involucrin

1

4

High-throughput

0.437

High

465538

IGF1R
Insulin-like growth factor 1 receptor

1

18

High-throughput

0.437

High

551621

NFH
Neurofilament heavy polypeptide

1

9

High-throughput

0.437

High

556125

CADH1
Cadherin-1

1

5

High-throughput

0.437

High

577778

PLAK
Junction plakoglobin

1

6

High-throughput

0.437

High

582825

EZRI
Ezrin

1

2

High-throughput

0.437

High

592725

LEUK
Leukosialin

1

1

High-throughput

0.437

High

604010

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.437

High

610004

VGFR1
Vascular endothelial growth factor receptor 1

1

13

High-throughput

0.437

High

619828

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.437

High

627129

TYPH
Thymidine phosphorylase

1

2

High-throughput

0.437

High

635601

FILA
Filaggrin

1

10

High-throughput

0.437

High

638429

FPR1
fMet-Leu-Phe receptor

1

11

High-throughput

0.437

High

650203

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.437

High

652325

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.437

High

659133

LORI
Loricrin

1

1

High-throughput

0.437

High

690023

CRBB3
Beta-crystallin B3

1

2

High-throughput

0.437

High

692710

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.437

High

710281

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.437

High

710845

EPHB2
Ephrin type-B receptor 2

1

7

High-throughput

0.437

High

715613

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.437

High

760447

SDC2
Syndecan-2

1

1

High-throughput

0.437

High

762132

CNR2
Cannabinoid receptor 2

1

6

Small-scale

0.437

High

771134

APJ
Apelin receptor

1

7

High-throughput

0.437

High

787029

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

13

High-throughput

0.437

High

823589

ADH7
All-trans-retinol dehydrogenase [NAD(+)] ADH7

1

2

High-throughput

0.437

High

839562

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.437

High

854094

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.437

High

856719

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.437

High

873735

GSH0
Glutamate--cysteine ligase regulatory subunit

1

4

High-throughput

0.437

High

878477

PAXI
Paxillin

1

1

High-throughput

0.437

High

892108

KLK7
Kallikrein-7

1

5

High-throughput

0.437

High

922256

LIMK1
LIM domain kinase 1

1

11

High-throughput

0.437

High

936059

PAR2
Proteinase-activated receptor 2

1

17

High-throughput

0.437

High

946555

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.437

High

964016

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.437

High

966397

1433G
14-3-3 protein gamma

1

20

High-throughput

0.437

High

1022399

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.437

High

1036736

DSG1
Desmoglein-1

1

7

High-throughput

0.437

High

1036991

DSC2
Desmocollin-2

1

7

High-throughput

0.437

High

1049356

1433F
14-3-3 protein eta

1

20

High-throughput

0.437

High

1086605

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.437

High

1091294

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.437

High

1105027

TCOF
Treacle protein

1

5

Small-scale

0.437

High

1113261

CUL3
Cullin-3

1

1

High-throughput

0.437

High

1134459

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.437

High

1140369

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.437

High

1144009

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.437

High

1149502

CDSN
Corneodesmosin

1

2

High-throughput

0.437

High

1156504

CCDC6
Coiled-coil domain-containing protein 6

1

10

High-throughput

0.437

High

1159377

ECM1
Extracellular matrix protein 1

1

2

High-throughput

0.437

High

1176978

INF2
Inverted formin-2

1

2

High-throughput

0.437

High

1186100

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

1195646

DJC21
DnaJ homolog subfamily C member 21

1

3

High-throughput

0.437

High

1195647

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

1

High-throughput

0.437

High

1195648

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.437

High

1195650

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

1195651

PLBL1
Phospholipase B-like 1

1

2

High-throughput

0.437

High

1195652

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.437

High

1195653

SBSN
Suprabasin

1

2

High-throughput

0.437

High

1195656

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1195657

FBX50
F-box only protein 50

1

2

High-throughput

0.437

High

1195659

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.437

High

1195661

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

17

High-throughput

0.437

High

1195662

SPA12
Serpin A12

1

11

High-throughput

0.437

High

1195664

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.437

High

1195665

ARRD4
Arrestin domain-containing protein 4

1

13

High-throughput

0.437

High

1195666

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

3

High-throughput

0.437

High

1195668

DNJB8
DnaJ homolog subfamily B member 8

1

4

High-throughput

0.437

High

1195670

PKR1
Prokineticin receptor 1

1

9

High-throughput

0.437

High

1195671

POF1B
Protein POF1B

1

2

High-throughput

0.437

High

1195672

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.437

High

1195673

ESR2
Estrogen receptor beta

1

9

High-throughput

0.437

High

1195674

EVPL
Envoplakin

1

11

High-throughput

0.437

High

1195675

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

6

High-throughput

0.437

High

1195677

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.437

High

1195678

ARRD3
Arrestin domain-containing protein 3

1

13

High-throughput

0.437

High

1195680

SNX27
Sorting nexin-27

1

2

High-throughput

0.437

High

1195681

CMIP5
Ciliary microtubule inner protein 5

1

1

High-throughput

0.437

High

1195683

OPALI
Opalin

1

1

High-throughput

0.437

High

1195684

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.437

High

1195685

SORT
Sortilin

1

2

High-throughput

0.437

High

1195687

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.437

High

1195689

CD244
Natural killer cell receptor 2B4

1

2

High-throughput

0.437

High

1195691

RNAS7
Ribonuclease 7

1

2

High-throughput

0.437

High

1195692

TXNIP
Thioredoxin-interacting protein

1

13

High-throughput

0.437

High

1195693

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.437

High

1195695

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1195696

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.437

High

1195698

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.437

High

1195701

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.437

High

1195702

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1195705

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

12

High-throughput

0.437

High

1195706

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.437

High

1195707

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1195709

SPB13
Serpin B13

1

8

High-throughput

0.437

High

1195710

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.437

High

1195711

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.437

High

1195716

GPR55
G-protein coupled receptor 55

1

20

High-throughput

0.437

High

1195717

KLK5
Kallikrein-5

1

5

High-throughput

0.437

High

1195720

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.437

High

1195721

NPTN
Neuroplastin

1

2

High-throughput

0.437

High

830848

CCNF
Cyclin-F

1

0

High-throughput

0.269

Low

1195708

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.269

Low

50864

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.249

Low

124367

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

137733

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

565402

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

872393

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

1135696

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1159674

OCLN
Occludin

1

0

High-throughput

0.249

Low

1178165

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1195649

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1195654

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1195655

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1195676

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1195682

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1195690

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025