HitPredict - High confidence protein-protein interactions

Interactor 1: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	24081328, 33503405, 17006541
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BRCT~BRCT, BRCT~PTCB-BRCT, BRCT~TopBP1_BRCT0, PTCB-BRCT~PTCB-BRCT, PTCB-BRCT~TopBP1_BRCT0
Common GO terms	GO:0000076 - DNA replication checkpoint signaling GO:0000077 - DNA damage checkpoint signaling GO:0000724 - double-strand break repair via homologous recombination GO:0000794 - condensed nuclear chromosome GO:0000922 - spindle pole and 30 others more... GO:0001673 - male germ cell nucleus GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005886 - plasma membrane GO:0006259 - DNA metabolic process GO:0006270 - DNA replication initiation GO:0006281 - DNA repair GO:0006974 - DNA damage response GO:0007095 - mitotic G2 DNA damage checkpoint signaling GO:0010212 - response to ionizing radiation GO:0015629 - actin cytoskeleton GO:0016604 - nuclear body GO:0016605 - PML body GO:0033314 - mitotic DNA replication checkpoint signaling GO:0035825 - homologous recombination GO:0035861 - site of double-strand break GO:0043539 - protein serine/threonine kinase activator activity GO:0051276 - chromosome organization GO:0070532 - BRCA1-B complex GO:0090734 - site of DNA damage GO:0097680 - double-strand break repair via classical nonhomologous end joining GO:0097681 - double-strand break repair via alternative nonhomologous end joining GO:0140031 - phosphorylation-dependent protein binding GO:0140463 - chromatin-protein adaptor activity GO:0141112 - broken chromosome clustering GO:1990166 - protein localization to site of double-strand break
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	1522
Hs

1	1522

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Last updated: 11Aug2025