HitPredict

Interactor 1: PCDA8 (Q9Y5H6)
Protocadherin alpha-8 (PCDH-alpha-8)
Gene: PCDHA8

Interactor 2: PCDA2 (Q9Y5H9)
Protocadherin alpha-2 (PCDH-alpha-2)
Gene: PCDHA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0007399 - nervous system development
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 950 Hs			1 948
+	Hs
		1357416 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDA4_HUMAN (1-948): 0: 1116: 83.02
+	Hs
		1378055 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDA1_HUMAN (1-948): 0: 1107: 83.26
+	Hs
		1357406 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDA7_HUMAN (1-948): 0: 1106: 80.17
+	Hs
		1378051 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDA3_HUMAN (1-948): 0: 1106: 82.53
+	Hs
		1378053 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDAD_HUMAN (1-948): 0: 1106: 82.00
+	Hs
		1357409 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDA6_HUMAN (1-948): 0: 1104: 80.63
+	Hs
		1357419 PCDA1_HUMAN (25-950): 0: 1057: 81.53		PCDA4_HUMAN (1-948): 0: 1116: 83.02
+	Hs
		1357410 PCDA6_HUMAN (23-950): 0: 1059: 91.49		PCDA3_HUMAN (1-948): 0: 1106: 82.53
+	Hs
		1357407 PCDA2_HUMAN (1-950): 0: 1058: 79.47		PCDA7_HUMAN (1-948): 0: 1106: 80.17
+	Hs
		1378061 PCDA1_HUMAN (25-950): 0: 1057: 81.53		PCDA3_HUMAN (1-948): 0: 1106: 82.53
+	Hs
		1357425 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDAC_HUMAN (1-948): 0: 1079: 80.49
+	Hs
		1378054 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDAA_HUMAN (22-948): 0: 1079: 81.16
+	Hs
		1378063 PCDAD_HUMAN (1-950): 0: 1063: 80.84		PCDAA_HUMAN (22-948): 0: 1079: 81.16
+	Hs
		1357411 PCDA6_HUMAN (23-950): 0: 1059: 91.49		PCDAA_HUMAN (22-948): 0: 1079: 81.16
+	Hs
		1378062 PCDA2_HUMAN (1-950): 0: 1058: 79.47		PCDAA_HUMAN (22-948): 0: 1079: 81.16
+	Hs
		1378045 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDGA_HUMAN (1-896): 0: 986: 38.04
+	Hs
		1378056 PCDA8_HUMAN (1-950): 0: 1071: 100.00		PCDC2_HUMAN (4-447): 1.79e-96: 328: 25.55