HitPredict

Interactor 1: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 26802121, 18462684, 29111346, 28249776, 17030804, 30561431, 36916940, 21803029, 12612076, 16611882, 12435599, 17000764, 19422324, 21988832, 23131831, 24266532, 16818647, 18617513, 20211142, 14743216
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, two hybrid, in-gel kinase assay, static light scattering, molecular sieving, cosedimentation in solution, virotrap, two hybrid array and 1 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains CC2-LZ~CC2-LZ, NEMO~NEMO
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000922 - spindle pole
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 32 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 419
Hs

1 419
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+ Dm
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Last updated: 15 Jul 2024