HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: MLP3A (Q9H492)
Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A)
Gene: MAP1LC3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	21617041, 37219487, 25026213
Identification Methods	pull down, affinity chromatography technology, unspecified method, two hybrid, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 121
+	Hs
		1123810 DCTN1_HUMAN (199-553): 4.08e-55: 203: 17.53		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		952289 OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		1386571 OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		328104 OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00		GBRAP_HUMAN (7-121): 3.01e-52: 161: 30.44
+	Hs
		1386565 OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00		MLP3C_HUMAN (1-120): 5.65e-51: 159: 59.17
+	Hs
		1386575 OPTN_HUMAN (1-577): 1.55e-48: 179: 100.00		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05
+	Mm
		1317373 OPTN_MOUSE (1-577): 1.84e-40: 156: 75.64		MLP3A_MOUSE (1-121): 4.21e-54: 167: 100.00
+	Hs
		587803 DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77		MLP3A_HUMAN (1-121): 4.21e-54: 167: 100.00
+	Hs
		587605 DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77		GBRL2_HUMAN (7-121): 5.56e-54: 166: 41.74
+	Hs
		327782 DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77		GBRAP_HUMAN (7-121): 3.01e-52: 161: 30.44
+	Hs
		587797 DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77		MLP3B_HUMAN (1-121): 6.68e-52: 161: 81.82
+	Hs
		587800 DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05
+	Hs
		773013 MYH9_HUMAN (194-572): 1.9e-13: 76: 14.81		GBRL1_HUMAN (3-120): 5.99e-51: 158: 33.05