HitPredict

Interactor 1: PRDX6 (O08709)
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx)
Gene: PRDX6

Interactor 2: THIOM (P97493)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: Txn2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31018154
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 224 Mm			1 166
+	Mm
		956730 PRDX2_MOUSE (2-204): 2.2e-89: 263: 28.50		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		727682 PRDX1_MOUSE (2-204): 1.64e-85: 253: 29.33		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		139927 PRDX4_MOUSE (3-204): 2.58e-83: 250: 25.24		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		589514 PRDX3_MOUSE (6-204): 2.35e-83: 250: 25.62		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Ss
		852787 P73348_SYNY3 (4-224): 4.38e-87: 258: 52.49		THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78
+	Dm
		1177773 Q7JX87_DROME (5-221): 6.7e-89: 263: 53.67		THIO2_DROME (61-162): 1.4e-36: 123: 37.86
+	Hs
		495475 PRDX2_HUMAN (2-204): 2.2e-89: 263: 28.50		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	So
		188731 BAS1_SPIOL (6-203): 2.56e-81: 245: 29.21		TRXM_SPIOL (14-165): 2.43e-39: 133: 23.03
+	Hs
		495510 PRDX1_HUMAN (2-204): 4.46e-86: 255: 28.85		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	Ss
		852841 P73348_SYNY3 (4-224): 4.38e-87: 258: 52.49		THIO1_SYNY3 (65-151): 3.22e-34: 117: 31.03
+	Hs
		423216 PRDX4_HUMAN (3-204): 3.43e-82: 247: 25.24		PDIA1_HUMAN (52-166): 3.4e-34: 127: 27.50
+	At
		1227668 BAS1B_ARATH (6-203): 4.34e-81: 244: 28.08		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Hs
		1026686 PRDX4_HUMAN (3-204): 3.43e-82: 247: 25.24		PDIA6_HUMAN (62-165): 2.6e-32: 121: 23.81
+	Dm
		1177800 Q7JX87_DROME (5-221): 6.7e-89: 263: 53.67		Q9W022_DROME (62-161): 5.31e-29: 105: 49.00
+	At
		1227667 BAS1A_ARATH (6-203): 3.01e-80: 242: 28.57		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Sc
		630634 PRX1_YEAST (4-221): 8.59e-80: 241: 47.73		TRX3_YEAST (47-164): 7.06e-37: 125: 29.66
+	Hs
		531737 PRDX3_HUMAN (6-204): 6.49e-84: 251: 25.62		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Hs
		671804 PRDX4_HUMAN (3-204): 3.43e-82: 247: 25.24		PDIA3_HUMAN (49-163): 5.5e-30: 115: 23.53
+	Hs
		531815 PRDX4_HUMAN (3-204): 3.43e-82: 247: 25.24		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Rn
		751965 PRDX4_RAT (3-204): 6.66e-83: 249: 25.24		PDIA4_RAT (16-165): 5.3e-28: 110: 23.23