HitPredict

Interactor 1: DNM3L (Q9CWR8)
DNA (cytosine-5)-methyltransferase 3-like
Gene: Dnmt3l

Interactor 2: DNM3L (Q9CWR8)
DNA (cytosine-5)-methyltransferase 3-like
Gene: Dnmt3l

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

The method score is based on:

Property	Details
Experiments	17713477
Identification Methods	molecular sieving
Interaction Type	direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	ADD_DNMT3~ADD_DNMT3, ADD_DNMT3~DNMT3_ADD_GATA1-like, DNMT3_ADD_GATA1-like~DNMT3_ADD_GATA1-like
Common GO terms	GO:0000792 - heterochromatin GO:0000794 - condensed nuclear chromosome GO:0001890 - placenta development GO:0005634 - nucleus GO:0005654 - nucleoplasm and 20 others more... GO:0005737 - cytoplasm GO:0006346 - DNA methylation-dependent constitutive heterochromatin formation GO:0007141 - male meiosis I GO:0007283 - spermatogenesis GO:0008047 - enzyme activator activity GO:0008270 - zinc ion binding GO:0009791 - post-embryonic development GO:0019899 - enzyme binding GO:0032259 - methylation GO:0044027 - negative regulation of gene expression via chromosomal CpG island methylation GO:0044726 - epigenetic programing of female pronucleus GO:0045814 - negative regulation of gene expression, epigenetic GO:0048863 - stem cell differentiation GO:0060718 - chorionic trophoblast cell differentiation GO:0071514 - genomic imprinting GO:0090310 - negative regulation of DNA methylation-dependent heterochromatin formation GO:0141005 - transposable element silencing by heterochromatin formation GO:0141068 - autosome genomic imprinting GO:0141196 - transposable element silencing by piRNA-mediated DNA methylation GO:1902494 - catalytic complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	421
Mm

1	421

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Mm

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Mm

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Hs

+

Hs

+

Mm

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Hs

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Hs

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Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025