Interactor 1: DNM3L (Q9UJW3)
DNA (cytosine-5)-methyltransferase 3-like
Gene: DNMT3L
Interactor 2: DNM3A (Q9Y6K1)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
Gene: DNMT3A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25383530, 15105426, 11934864, 17687327, 12777184, 15861382, 20211142 |
| Identification Methods | x-ray crystallography, pull down, affinity chromatography technology, two hybrid, transmission electron microscopy, molecular sieving, two hybrid array |
| Interaction Type | association, direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | ADD_DNMT3~ADD_DNMT3, ADD_DNMT3~DNA_methylase, ADD_DNMT3~DNMT3_ADD_GATA1-like, DNMT3_ADD_GATA1-like~DNMT3_ADD_GATA1-like |
| Common GO terms | GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006346 - DNA methylation-dependent constitutive heterochromatin formation GO:0007283 - spermatogenesis and 8 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
