HitPredict

Interactor 1: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Interactor 2: CUED1 (Q9NWM3)
CUE domain-containing protein 1
Gene: CUEDC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.630

Property	Details
Experiments	33099540, 33961781, 15231748, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 748 Hs			1 386
+	Hs
		1438985 SMUF1_HUMAN (1-748): 0: 753: 70.31		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1400036 NED4L_HUMAN (5-394): 5.06e-38: 154: 18.24		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1394626 ITCH_HUMAN (1-426): 1.04e-26: 118: 17.13		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		132341 WWP2_HUMAN (1-416): 3.08e-25: 114: 15.94		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1430217 WWP1_HUMAN (2-430): 3.39e-22: 104: 13.94		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1451224 HECW2_HUMAN (19-281): 1.72e-15: 83.3: 13.46		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1260712 HECW1_HUMAN (19-213): 2.92e-15: 82.5: 15.94		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		861806 NEDD4_HUMAN (88-375): 9.05e-14: 77.5: 16.67		CUED1_HUMAN (1-386): 0: 606: 100.00