Protein: HECW1
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)

Gene: HECW1
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q76N89

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0048814 - regulation of dendrite morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1260709

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.698

High

1260708

MPP8
M-phase phosphoprotein 8

1

12

High-throughput

0.691

High

508187

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

906687

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

957112

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

982221

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.647

High

995982

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1260698

HECW1
E3 ubiquitin-protein ligase HECW1

1

17

Small-scale

0.647

High

1260701

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

Small-scale

0.647

High

181002

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

4

12

High-throughput

0.630

High

862247

YAP1
Transcriptional coactivator YAP1

1

19

Small-scale

0.618

High

1260713

HECW2
E3 ubiquitin-protein ligase HECW2

1

17

High-throughput

0.618

High

1260714

HERC5
E3 ISG15--protein ligase HERC5

1

17

Small-scale

0.618

High

1010488

EREP3
Protein ENTREP3

3

15

High-throughput

0.604

High

1260704

DLG3
Disks large homolog 3

1

10

High-throughput

0.575

High

414084

P53
Cellular tumor antigen p53

1

15

Small-scale

0.561

High

1210143

VAX1
Ventral anterior homeobox 1

2

2

High-throughput

0.553

High

159368

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.552

High

1228978

RNF43
E3 ubiquitin-protein ligase RNF43

1

8

Small-scale

0.552

High

1260703

TSC1
Hamartin

1

12

High-throughput

0.541

High

1260700

ILDR1
Immunoglobulin-like domain-containing receptor 1

1

5

High-throughput

0.536

High

1260711

FXL15
F-box/LRR-repeat protein 15

1

10

Small-scale

0.515

High

139717

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

20

High-throughput

0.508

High

1260705

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

15

High-throughput

0.508

High

788533

SCNNA
Epithelial sodium channel subunit alpha

1

20

Small-scale

0.501

High

1060792

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.501

High

1260710

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

14

Small-scale

0.489

High

160930

TMG1
Transmembrane gamma-carboxyglutamic acid protein 1

1

14

High-throughput

0.489

High

1260702

TM171
Transmembrane protein 171

1

4

High-throughput

0.489

High

361285

SODC
Superoxide dismutase [Cu-Zn]

1

4

Small-scale

0.479

High

1217732

GFI1B
Zinc finger protein Gfi-1b

1

1

High-throughput

0.464

High

1260699

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

902323

SCNNB
Epithelial sodium channel subunit beta

1

20

Small-scale

0.457

High

1260706

ARRD3
Arrestin domain-containing protein 3

1

20

High-throughput

0.445

High

903721

SSRD
Translocon-associated protein subunit delta

1

2

Small-scale

0.437

High

1260712

CUED1
CUE domain-containing protein 1

1

8

High-throughput

0.407

High

1260707

ZN707
Zinc finger protein 707

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025