HitPredict

Interactor 1: UBE2T (Q9NPD8)
Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)
Gene: UBE2T

Interactor 2: MARH5 (Q9NX47)
E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)
Gene: MARCHF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0044314 - protein K27-linked ubiquitination GO:0051865 - protein autoubiquitination GO:0070534 - protein K63-linked ubiquitination GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 278
+	Hs
		906798 UB2D1_HUMAN (2-152): 4.33e-77: 229: 41.72		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Hs
		982340 UB2D2_HUMAN (2-152): 5.63e-77: 229: 41.72		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Hs
		957217 UB2D3_HUMAN (2-152): 1.08e-75: 225: 41.06		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Hs
		957852 UBE2N_HUMAN (4-152): 1.42e-70: 212: 44.97		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Hs
		1381209 UB2E3_HUMAN (3-152): 2.35e-68: 209: 40.00		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Hs
		909398 UB2E1_HUMAN (3-152): 2.32e-67: 206: 40.00		MARH5_HUMAN (1-278): 1.38e-162: 454: 100.00
+	Dm
		762723 UBE2N_DROME (2-151): 5.25e-71: 213: 46.67		Q9VB61_DROME (10-278): 9.73e-143: 404: 39.71