Protein: MARH5
E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)

Gene: MARH5, MARCHF5
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q9NX47

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

326623

MFN2
Mitofusin-2

8

3

Small-scale

0.751

High

982340

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

6

Small-scale

0.744

High

1451777

MARH5
E3 ubiquitin-protein ligase MARCHF5

5

1

Small-scale

0.707

High

1383939

UBE2W
Ubiquitin-conjugating enzyme E2 W

4

7

High-throughput

0.700

High

906798

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

6

Small-scale

0.688

High

1309742

MFN1
Mitofusin-1

4

3

Small-scale

0.676

High

135719

DNM1L
Dynamin-1-like protein

4

0

Small-scale

0.648

High

1278130

MAVS
Mitochondrial antiviral-signaling protein

4

0

Small-scale

0.648

High

1366597

AKAP1
A-kinase anchor protein 1, mitochondrial

3

1

Small-scale

0.640

High

1206161

TGO1
Transport and Golgi organization protein 1 homolog

3

0

High-throughput

0.638

High

1164597

MIC60
MICOS complex subunit MIC60

2

1

Small-scale

0.624

High

1379887

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.601

High

318067

TOM70
Mitochondrial import receptor subunit TOM70

2

1

Small-scale

0.584

High

333232

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

1

Small-scale

0.584

High

1147753

MTFR1
Mitochondrial fission regulator 1

2

1

Small-scale

0.584

High

1312284

MIRO2
Mitochondrial Rho GTPase 2

2

1

Small-scale

0.584

High

1386390

FAF2
FAS-associated factor 2

2

1

Small-scale

0.584

High

1451792

TDRKH
Tudor and KH domain-containing protein

2

1

Small-scale

0.584

High

144496

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

325615

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

337829

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.580

High

932602

PTN5
Tyrosine-protein phosphatase non-receptor type 5

2

0

High-throughput

0.580

High

1091991

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.580

High

1178725

ODFP4
Outer dense fiber protein 4

2

0

High-throughput

0.580

High

1279382

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1308352

TM139
Transmembrane protein 139

2

0

High-throughput

0.580

High

1352536

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

1359813

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

2

0

High-throughput

0.580

High

1406329

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.580

High

1446588

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.580

High

1447074

MANBL
Protein MANBAL

2

0

High-throughput

0.580

High

1447897

SAR1A
Small COPII coat GTPase SAR1A

2

0

High-throughput

0.580

High

1451791

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

316075

RECQ4
ATP-dependent DNA helicase Q4

1

1

Small-scale

0.578

High

701925

ABCD3
ATP-binding cassette sub-family D member 3

2

0

Small-scale

0.576

High

828459

PEX19
Peroxisomal biogenesis factor 19

2

0

Small-scale

0.576

High

941980

PEX3
Peroxisomal biogenesis factor 3

2

0

Small-scale

0.576

High

230448

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

538007

HSP7C
Heat shock cognate 71 kDa protein

2

0

Small-scale

0.559

High

611383

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

0

Small-scale

0.559

High

1258008

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

0

Small-scale

0.559

High

1332672

MIGA1
Mitoguardin 1

2

0

Small-scale

0.559

High

1382959

S2546
Mitochondrial outer membrane protein SLC25A46

2

0

Small-scale

0.559

High

1403809

RMD3
Regulator of microtubule dynamics protein 3

2

0

Small-scale

0.559

High

1429141

MFF
Mitochondrial fission factor

2

0

Small-scale

0.559

High

1451724

OCAD1
OCIA domain-containing protein 1

2

0

Small-scale

0.559

High

1390569

Q96FI0
Ubiquitin-conjugating enzyme E2 W

2

6

High-throughput

0.558

High

926129

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.554

High

1309035

FUND1
FUN14 domain-containing protein 1

1

0

Small-scale

0.554

High

1449798

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

957852

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

7

High-throughput

0.541

High

1436470

AKTIP
AKT-interacting protein

1

6

High-throughput

0.541

High

1446243

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

7

High-throughput

0.541

High

282629

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.537

High

361365

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.537

High

1369499

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.537

High

1273289

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1451784

O12D3
Olfactory receptor 12D3

1

0

High-throughput

0.513

High

1451785

FLOWR
Calcium channel flower homolog

1

0

High-throughput

0.513

High

909398

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.501

High

957217

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

6

Small-scale

0.501

High

1381209

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

6

Small-scale

0.501

High

993778

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.494

High

508724

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.493

High

1451793

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.493

High

1451786

DPOG2
DNA polymerase subunit gamma-2

1

0

Small-scale

0.480

High

245551

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

Small-scale

0.479

High

276183

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.479

High

299399

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

354414

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

Small-scale

0.479

High

420720

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.479

High

461981

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

468851

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

598220

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

634664

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

852869

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

Small-scale

0.479

High

935193

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

1108212

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1124930

FLOT2
Flotillin-2

1

1

High-throughput

0.479

High

1216566

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

High-throughput

0.479

High

1242130

MTFR2
Mitochondrial fission regulator 2

1

1

High-throughput

0.479

High

1246026

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

2

High-throughput

0.479

High

1349905

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

3

High-throughput

0.479

High

1365069

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

1402831

TM209
Transmembrane protein 209

1

1

High-throughput

0.479

High

1409612

NIPS1
Protein NipSnap homolog 1

1

1

High-throughput

0.479

High

1450496

DJC11
DnaJ homolog subfamily C member 11

1

1

High-throughput

0.479

High

1450577

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

1451781

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

1451782

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

3

High-throughput

0.479

High

1451783

DNJB9
DnaJ homolog subfamily B member 9

1

1

Small-scale

0.479

High

1451789

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.479

High

181447

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.458

High

192329

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

209124

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.458

High

211062

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.458

High

243112

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.458

High

278984

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

281106

TACC1
Transforming acidic coiled-coil-containing protein 1

1

0

High-throughput

0.458

High

317009

MTA2
Metastasis-associated protein MTA2

1

0

Small-scale

0.458

High

326070

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

329598

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

345121

RIGI
Antiviral innate immune response receptor RIG-I

1

0

Small-scale

0.458

High

354477

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.458

High

457136

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.458

High

504767

FBSP1
F-box/SPRY domain-containing protein 1

1

0

Small-scale

0.458

High

566465

K2C5
Keratin, type II cytoskeletal 5

1

0

High-throughput

0.458

High

568860

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

High-throughput

0.458

High

573898

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

584816

NDKA
Nucleoside diphosphate kinase A

1

0

High-throughput

0.458

High

621537

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

647672

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

Small-scale

0.458

High

696679

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

699190

CALX
Calnexin

1

0

Small-scale

0.458

High

727993

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.458

High

732857

GLPK
Glycerol kinase

1

0

High-throughput

0.458

High

896318

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.458

High

906198

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

916203

BIEA
Biliverdin reductase A

1

0

High-throughput

0.458

High

968817

PRS4
26S proteasome regulatory subunit 4

1

0

Small-scale

0.458

High

992357

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1005166

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1058688

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1063193

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.458

High

1111728

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1125697

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1128491

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

Small-scale

0.458

High

1128845

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1132347

GOGB1
Golgin subfamily B member 1

1

0

High-throughput

0.458

High

1136391

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1147697

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

1152881

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.458

High

1214587

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1219357

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

Small-scale

0.458

High

1228782

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

Small-scale

0.458

High

1241418

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

Small-scale

0.458

High

1258286

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

0

Small-scale

0.458

High

1259165

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

1293827

FBX11
F-box only protein 11

1

0

Small-scale

0.458

High

1294017

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

1294513

VRK2
Serine/threonine-protein kinase VRK2

1

0

High-throughput

0.458

High

1312432

ASXL1
Polycomb group protein ASXL1

1

0

Small-scale

0.458

High

1315656

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.458

High

1316087

ELMD2
ELMO domain-containing protein 2

1

0

Small-scale

0.458

High

1327982

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.458

High

1360683

SYNE2
Nesprin-2

1

0

High-throughput

0.458

High

1382217

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1386606

OPTN
Optineurin

1

0

High-throughput

0.458

High

1388008

S2538
Mitochondrial glycine transporter

1

0

Small-scale

0.458

High

1392680

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.458

High

1393761

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1399398

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

Small-scale

0.458

High

1402387

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1404593

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.458

High

1405880

DNJC7
DnaJ homolog subfamily C member 7

1

0

Small-scale

0.458

High

1406193

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

0

High-throughput

0.458

High

1416990

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.458

High

1432761

TMX1
Thioredoxin-related transmembrane protein 1

1

0

Small-scale

0.458

High

1433695

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

1447110

MID51
Mitochondrial dynamics protein MIEF1

1

0

High-throughput

0.458

High

1448024

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1450447

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1451778

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.458

High

1451779

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1451787

NB5R1
NADH-cytochrome b5 reductase 1

1

0

Small-scale

0.458

High

1451788

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

1451794

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.458

High

1451796

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.458

High

1180330

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.445

High

1337980

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

1346805

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

1451780

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.445

High

1451795

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.445

High

231773

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.437

High

451286

NFL
Neurofilament light polypeptide

1

1

High-throughput

0.437

High

1112270

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.437

High

1258269

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

1

Small-scale

0.437

High

1393252

GRM2B
GRAM domain-containing protein 2B

3

0

High-throughput

0.347

High

1451790

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

1102460

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1109075

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1228817

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

2

0

High-throughput

0.316

High

1430836

STMN4
Stathmin-4

2

0

High-throughput

0.316

High

220718

DENR
Density-regulated protein

2

0

Small-scale

0.305

High

861313

MAP1B
Microtubule-associated protein 1B

1

0

Small-scale

0.292

High

1116312

PTC1
Protein patched homolog 1

1

0

High-throughput

0.279

Low

1351561

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

High-throughput

0.279

Low

246989

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.249

Low

1434051

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1437514

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

1447130

DDX4
Probable ATP-dependent RNA helicase DDX4

1

0

High-throughput

0.249

Low

276795

TBCA
Tubulin-specific chaperone A

1

0

Small-scale

0.249

Low

321052

SUN1
SUN domain-containing protein 1

1

0

High-throughput

0.249

Low

373304

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

589860

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

668733

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.249

Low

927154

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

976606

RB11A
Ras-related protein Rab-11A

1

0

Small-scale

0.249

Low

977598

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

0

Small-scale

0.249

Low

988224

TRA2B
Transformer-2 protein homolog beta

1

0

Small-scale

0.249

Low

1032429

OTUD4
OTU domain-containing protein 4

1

0

Small-scale

0.249

Low

1099283

SRSF5
Serine/arginine-rich splicing factor 5

1

0

Small-scale

0.249

Low

1159942

MEA1
Male-enhanced antigen 1

1

0

Small-scale

0.249

Low

1210123

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

1353214

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

1358932

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

Small-scale

0.249

Low

1371734

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.249

Low

1379906

NKD2
Protein naked cuticle homolog 2

1

0

Small-scale

0.249

Low

1397489

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

65416

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.232

Low

1260510

S35D2
Nucleotide sugar transporter SLC35D2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025