Protein: EYA4
Eyes absent homolog 4 (EC 3.1.3.48)

Gene: EYA4
Organism: Homo sapiens
Interactions: 243
UniProt ID: O95677

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006281 - DNA repair
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

318622

SIX1
Homeobox protein SIX1

5

20

High-throughput

0.915

High

318733

SIX2
Homeobox protein SIX2

3

20

High-throughput

0.861

High

318748

SIX4
Homeobox protein SIX4

2

20

High-throughput

0.789

High

318550

EYA4
Eyes absent homolog 4

2

15

High-throughput

0.754

High

318670

SIX5
Homeobox protein SIX5

1

20

High-throughput

0.691

High

318577

MK01
Mitogen-activated protein kinase 1

2

2

Small-scale

0.634

High

318724

DCTP1
dCTP pyrophosphatase 1

3

0

High-throughput

0.628

High

118524

EYA2
Eyes absent homolog 2

1

14

High-throughput

0.618

High

318706

EYA1
Eyes absent homolog 1

1

18

High-throughput

0.618

High

318725

AT133
Polyamine-transporting ATPase 13A3

1

3

High-throughput

0.618

High

318747

PFD2
Prefoldin subunit 2

2

3

High-throughput

0.611

High

318703

CIC
Protein capicua homolog

2

20

High-throughput

0.584

High

318591

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.578

High

318661

TRI69
E3 ubiquitin-protein ligase TRIM69

1

1

Small-scale

0.561

High

123820

SPT5H
Transcription elongation factor SPT5

1

13

High-throughput

0.536

High

318563

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

318569

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.536

High

318580

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.536

High

318663

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

5

High-throughput

0.536

High

318742

FOXJ2
Forkhead box protein J2

1

9

High-throughput

0.536

High

215405

SCO2
Protein SCO2 homolog, mitochondrial

2

3

High-throughput

0.533

High

276770

SCO1
Protein SCO1 homolog, mitochondrial

2

3

High-throughput

0.533

High

318553

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.501

High

318562

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

318570

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

9

High-throughput

0.494

High

318651

LMTK1
Serine/threonine-protein kinase LMTK1

1

14

High-throughput

0.494

High

65014

SOBP
Sine oculis-binding protein homolog

1

8

High-throughput

0.479

High

123154

CBX4
E3 SUMO-protein ligase CBX4

1

7

High-throughput

0.479

High

160306

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

164170

ZN609
Zinc finger protein 609

1

10

High-throughput

0.479

High

174513

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.479

High

225698

SOX15
Transcription factor SOX-15

1

19

High-throughput

0.479

High

270465

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

277461

CCNK
Cyclin-K

1

7

High-throughput

0.479

High

299544

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

2

High-throughput

0.479

High

317648

CNOT4
CCR4-NOT transcription complex subunit 4

1

1

High-throughput

0.479

High

318551

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

318552

RASK
GTPase KRas

1

8

Small-scale

0.479

High

318554

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

Small-scale

0.479

High

318555

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.479

High

318556

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

5

High-throughput

0.479

High

318557

JUN
Transcription factor Jun

1

10

High-throughput

0.479

High

318558

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

318559

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.479

High

318560

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

318567

ITF2
Transcription factor 4

1

1

High-throughput

0.479

High

318568

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

318572

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

18

Small-scale

0.479

High

318573

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

318574

GATA2
Endothelial transcription factor GATA-2

1

10

High-throughput

0.479

High

318575

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

318576

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

318579

TLX1
T-cell leukemia homeobox protein 1

1

17

High-throughput

0.479

High

318582

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

318583

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

Small-scale

0.479

High

318585

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

1

High-throughput

0.479

High

318587

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.479

High

318588

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.479

High

318590

TF2AA
Transcription initiation factor IIA subunit 1

1

1

High-throughput

0.479

High

318592

ATN1
Atrophin-1

1

14

High-throughput

0.479

High

318593

GSC
Homeobox protein goosecoid

1

11

High-throughput

0.479

High

318595

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.479

High

318597

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.479

High

318598

H4
Histone H4

1

5

High-throughput

0.479

High

318600

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.479

High

318601

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

5

High-throughput

0.479

High

318602

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.479

High

318603

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

2

High-throughput

0.479

High

318604

TIAR
Nucleolysin TIAR

1

5

High-throughput

0.479

High

318605

EWS
RNA-binding protein EWS

1

18

High-throughput

0.479

High

318606

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

3

Small-scale

0.479

High

318607

ERCC6
DNA excision repair protein ERCC-6

1

16

Small-scale

0.479

High

318608

LGUL
Lactoylglutathione lyase

1

1

High-throughput

0.479

High

318609

TLE5
TLE family member 5

1

6

High-throughput

0.479

High

318610

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

318612

CDC20
Cell division cycle protein 20 homolog

1

15

High-throughput

0.479

High

318613

TRI32
E3 ubiquitin-protein ligase TRIM32

1

2

High-throughput

0.479

High

318614

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.479

High

318615

GPS2
G protein pathway suppressor 2

1

1

High-throughput

0.479

High

318616

ATR
Serine/threonine-protein kinase ATR

1

1

High-throughput

0.479

High

318617

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.479

High

318620

PLEC
Plectin

1

3

High-throughput

0.479

High

318621

SF3B4
Splicing factor 3B subunit 4

1

9

High-throughput

0.479

High

318623

NCOA2
Nuclear receptor coactivator 2

1

6

High-throughput

0.479

High

318624

SF01
Splicing factor 1

1

12

High-throughput

0.479

High

318625

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

1

High-throughput

0.479

High

318626

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.479

High

318627

NCOA1
Nuclear receptor coactivator 1

1

6

High-throughput

0.479

High

318628

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.479

High

318629

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

20

High-throughput

0.479

High

318631

RFX7
DNA-binding protein RFX7

1

10

High-throughput

0.479

High

318634

GRDN
Girdin

1

3

High-throughput

0.479

High

318637

AMOT
Angiomotin

1

11

High-throughput

0.479

High

318639

PRC2B
Protein PRRC2B

1

20

High-throughput

0.479

High

318646

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.479

High

318649

WDR74
WD repeat-containing protein 74

1

17

High-throughput

0.479

High

318650

BCOR
BCL-6 corepressor

1

10

High-throughput

0.479

High

318653

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

318654

UBN2
Ubinuclein-2

1

10

High-throughput

0.479

High

318655

MCM10
Protein MCM10 homolog

1

1

High-throughput

0.479

High

318657

KHDC4
KH homology domain-containing protein 4

1

1

High-throughput

0.479

High

318659

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

12

High-throughput

0.479

High

318660

LUZP1
Leucine zipper protein 1

1

7

High-throughput

0.479

High

318664

TPPC5
Trafficking protein particle complex subunit 5

1

1

High-throughput

0.479

High

318665

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

3

High-throughput

0.479

High

318667

RAVR1
Ribonucleoprotein PTB-binding 1

1

12

High-throughput

0.479

High

318669

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

16

High-throughput

0.479

High

318676

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

6

High-throughput

0.479

High

318678

PUM2
Pumilio homolog 2

1

2

High-throughput

0.479

High

318682

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

318686

PSPC1
Paraspeckle component 1

1

17

High-throughput

0.479

High

318687

AUTS2
Autism susceptibility gene 2 protein

1

20

High-throughput

0.479

High

318688

MAML1
Mastermind-like protein 1

1

15

High-throughput

0.479

High

318689

CBP
CREB-binding protein

1

14

High-throughput

0.479

High

318693

DAZP1
DAZ-associated protein 1

1

10

High-throughput

0.479

High

318695

RBM33
RNA-binding protein 33

1

20

High-throughput

0.479

High

318696

ZN503
Zinc finger protein 503

1

2

High-throughput

0.479

High

318699

RBM14
RNA-binding protein 14

1

8

High-throughput

0.479

High

318700

QKI
KH domain-containing RNA-binding protein QKI

1

9

High-throughput

0.479

High

318704

MED15
Mediator of RNA polymerase II transcription subunit 15

1

16

High-throughput

0.479

High

318708

PITX2
Pituitary homeobox 2

1

12

High-throughput

0.479

High

318710

ANM1
Protein arginine N-methyltransferase 1

1

8

High-throughput

0.479

High

318711

PKP2
Plakophilin-2

1

2

High-throughput

0.479

High

318714

RBM42
RNA-binding protein 42

1

6

High-throughput

0.479

High

318716

RBM4
RNA-binding protein 4

1

12

High-throughput

0.479

High

318718

SSBP3
Single-stranded DNA-binding protein 3

1

12

High-throughput

0.479

High

318719

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

7

High-throughput

0.479

High

318720

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.479

High

318721

WDR33
pre-mRNA 3' end processing protein WDR33

1

13

High-throughput

0.479

High

318723

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

318726

ZN703
Zinc finger protein 703

1

7

High-throughput

0.479

High

318727

VP37B
Vacuolar protein sorting-associated protein 37B

1

1

High-throughput

0.479

High

318729

SENP2
Sentrin-specific protease 2

1

1

High-throughput

0.479

High

318740

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

318744

PEF1
Peflin

1

4

High-throughput

0.479

High

318745

UBQL2
Ubiquilin-2

1

10

High-throughput

0.479

High

318749

ANC2
Anaphase-promoting complex subunit 2

1

11

High-throughput

0.479

High

318750

ZN608
Zinc finger protein 608

1

9

High-throughput

0.479

High

318751

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

5

High-throughput

0.479

High

318752

PRR12
Proline-rich protein 12

1

19

High-throughput

0.479

High

318753

CIZ1
Cip1-interacting zinc finger protein

1

8

High-throughput

0.479

High

318756

FOXJ3
Forkhead box protein J3

1

9

High-throughput

0.479

High

318757

R3HD2
R3H domain-containing protein 2

1

14

High-throughput

0.479

High

318761

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

318762

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

318764

NCOA3
Nuclear receptor coactivator 3

1

6

High-throughput

0.479

High

172724

ZN185
Zinc finger protein 185

1

0

High-throughput

0.458

High

206263

RA51C
DNA repair protein RAD51 homolog 3

1

0

High-throughput

0.458

High

214812

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

303819

CCNB2
G2/mitotic-specific cyclin-B2

1

0

High-throughput

0.458

High

307933

ZWINT
ZW10 interactor

1

0

High-throughput

0.458

High

318564

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.458

High

318566

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

318571

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

318584

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

318589

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

318594

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

318596

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.458

High

318599

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

0

High-throughput

0.458

High

318611

TROAP
Tastin

1

0

High-throughput

0.458

High

318636

TPRN
Taperin

1

0

High-throughput

0.458

High

318645

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

318656

HDX
Highly divergent homeobox

1

0

High-throughput

0.458

High

318658

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.458

High

318671

HROB
Homologous recombination OB-fold protein

1

0

High-throughput

0.458

High

318680

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

0

High-throughput

0.458

High

318681

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

318698

CEP20
Centrosomal protein 20

1

0

High-throughput

0.458

High

318705

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

318709

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.458

High

318713

TCHP
Trichoplein keratin filament-binding protein

1

0

High-throughput

0.458

High

318715

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.458

High

318717

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.458

High

318731

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

318734

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.458

High

318735

LANC2
LanC-like protein 2

1

0

High-throughput

0.458

High

318737

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.458

High

318738

SPS2L
SPATS2-like protein

1

0

High-throughput

0.458

High

318743

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.458

High

318746

IP6K2
Inositol hexakisphosphate kinase 2

1

0

High-throughput

0.458

High

318754

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.458

High

318758

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

318759

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.458

High

87523

KBTBD
Kelch repeat and BTB domain-containing protein 13

1

1

High-throughput

0.437

High

128955

PLK4
Serine/threonine-protein kinase PLK4

1

3

High-throughput

0.437

High

131681

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

166200

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.437

High

200962

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.437

High

264665

VP26A
Vacuolar protein sorting-associated protein 26A

1

2

High-throughput

0.437

High

273647

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

315616

SC24B
Protein transport protein Sec24B

1

8

High-throughput

0.437

High

318561

CTF8
Chromosome transmission fidelity protein 8 homolog

1

1

High-throughput

0.437

High

318581

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.437

High

318586

CRKL
Crk-like protein

1

3

High-throughput

0.437

High

318618

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

318619

R3HD1
R3H domain-containing protein 1

1

19

High-throughput

0.437

High

318632

QSER1
Glutamine and serine-rich protein 1

1

19

High-throughput

0.437

High

318633

AAK1
AP2-associated protein kinase 1

1

6

High-throughput

0.437

High

318635

VP26B
Vacuolar protein sorting-associated protein 26B

1

2

High-throughput

0.437

High

318641

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

318642

DDI2
Protein DDI1 homolog 2

1

10

High-throughput

0.437

High

318643

WDR25
WD repeat-containing protein 25

1

11

High-throughput

0.437

High

318644

SPT2
Protein SPT2 homolog

1

13

High-throughput

0.437

High

318647

CEP85
Centrosomal protein of 85 kDa

1

6

High-throughput

0.437

High

318648

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

6

High-throughput

0.437

High

318652

CO039
Uncharacterized protein C15orf39

1

10

High-throughput

0.437

High

318662

PRSR1
Proline and serine-rich protein 1

1

17

High-throughput

0.437

High

318666

AMOL1
Angiomotin-like protein 1

1

8

High-throughput

0.437

High

318672

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

16

High-throughput

0.437

High

318674

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

9

High-throughput

0.437

High

318675

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

19

High-throughput

0.437

High

318679

ALMS1
Centrosome-associated protein ALMS1

1

15

High-throughput

0.437

High

318684

POF1B
Protein POF1B

1

1

High-throughput

0.437

High

318685

ATX2L
Ataxin-2-like protein

1

12

High-throughput

0.437

High

318690

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

2

High-throughput

0.437

High

318691

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

High-throughput

0.437

High

318692

SEH1
Nucleoporin SEH1

1

18

High-throughput

0.437

High

318712

RBM4B
RNA-binding protein 4B

1

11

High-throughput

0.437

High

318728

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

318730

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

19

High-throughput

0.437

High

318732

FBSL
Fibrosin-1-like protein

1

3

High-throughput

0.437

High

318736

RBM12
RNA-binding protein 12

1

8

High-throughput

0.437

High

318739

CARF
CDKN2A-interacting protein

1

1

High-throughput

0.437

High

318741

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.437

High

318755

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

9

High-throughput

0.437

High

318565

YJU2B
Probable splicing factor YJU2B

1

0

High-throughput

0.249

Low

318578

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.249

Low

318630

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.249

Low

318638

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.249

Low

318640

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

0

High-throughput

0.249

Low

318668

CKP2L
Cytoskeleton-associated protein 2-like

1

0

High-throughput

0.249

Low

318673

MTMRE
Myotubularin-related protein 14

1

0

High-throughput

0.249

Low

318677

FAD1
FAD synthase

1

0

High-throughput

0.249

Low

318683

F222B
Protein FAM222B

1

0

High-throughput

0.249

Low

318694

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.249

Low

318697

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.249

Low

318701

UIF
UAP56-interacting factor

1

0

High-throughput

0.249

Low

318702

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.249

Low

318707

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low

318722

FN3K
Fructosamine-3-kinase

1

0

High-throughput

0.249

Low

318760

LRC42
Leucine-rich repeat-containing protein 42

1

0

High-throughput

0.249

Low

318763

ORNT1
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024