HitPredict

Interactor 1: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Interactor 2: UB2J1 (Q9Y385)
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Gene: UBE2J1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1045 Hs			1 318
+	Hs
		1449085 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2D4_HUMAN (10-156): 6.34e-70: 215: 28.00
+	Hs
		982333 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2D2_HUMAN (10-156): 6.77e-70: 215: 28.00
+	Hs
		906794 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2D1_HUMAN (10-156): 1.34e-69: 214: 30.00
+	Hs
		957212 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2D3_HUMAN (10-156): 2.03e-68: 211: 28.00
+	Hs
		909395 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2E1_HUMAN (1-155): 4.54e-64: 202: 28.48
+	Hs
		1381207 TOPRS_HUMAN (1-1045): 0: 765: 100.00		UB2E3_HUMAN (2-155): 1.58e-62: 199: 26.75