Protein: TOPRS
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)

Gene: TOPRS, TOPORS
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9NS56

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000922 - spindle pole
GO:0000930 - gamma-tubulin complex
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906794

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

6

Small-scale

0.935

High

1381207

UB2E3
Ubiquitin-conjugating enzyme E2 E3

2

6

High-throughput

0.811

High

591856

H2AX
Histone H2AX

2

3

Small-scale

0.806

High

957212

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

6

Small-scale

0.800

High

982333

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

6

High-throughput

0.800

High

993769

UBC9
SUMO-conjugating enzyme UBC9

2

6

Small-scale

0.767

High

714449

PML
Protein PML

2

8

Small-scale

0.754

High

414699

P53
Cellular tumor antigen p53

6

5

Small-scale

0.729

High

168570

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

8

High-throughput

0.698

High

957850

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

High-throughput

0.698

High

1383937

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

6

High-throughput

0.698

High

1449085

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

6

High-throughput

0.698

High

1449086

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

6

High-throughput

0.698

High

1449088

SPIN1
Spindlin-1

4

1

High-throughput

0.691

High

320780

UBXN7
UBX domain-containing protein 7

4

0

High-throughput

0.674

High

542244

TOP1
DNA topoisomerase 1

3

6

Small-scale

0.667

High

1409754

SPI2B
Spindlin-2B

3

1

High-throughput

0.667

High

1418607

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

5

High-throughput

0.667

High

920301

PLK1
Serine/threonine-protein kinase PLK1

3

3

Small-scale

0.664

High

508695

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.647

High

909395

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.647

High

1449081

TOPRS
E3 ubiquitin-protein ligase Topors

1

7

High-throughput

0.647

High

171929

ZN263
Zinc finger protein 263

2

2

High-throughput

0.628

High

889820

CLK3
Dual specificity protein kinase CLK3

2

5

High-throughput

0.628

High

1081807

ZN816
Zinc finger protein 816

2

1

High-throughput

0.628

High

1230909

Z324B
Zinc finger protein 324B

2

3

High-throughput

0.628

High

1290758

ZCH18
Zinc finger CCCH domain-containing protein 18

2

5

High-throughput

0.628

High

1324940

ZN786
Zinc finger protein 786

2

1

High-throughput

0.628

High

1432366

PININ
Pinin

2

3

High-throughput

0.628

High

1449083

ZN214
Zinc finger protein 214

2

1

High-throughput

0.628

High

1100431

TIF1B
Transcription intermediary factor 1-beta

1

10

Small-scale

0.618

High

1348974

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.601

High

1055977

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.586

High

991438

SUMO1
Small ubiquitin-related modifier 1

2

3

Small-scale

0.584

High

1241045

L2GL2
LLGL scribble cell polarity complex component 2

2

1

High-throughput

0.574

High

1032785

SATB1
DNA-binding protein SATB1

2

0

Small-scale

0.570

High

968816

PRS4
26S proteasome regulatory subunit 4

1

2

Small-scale

0.552

High

617742

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.537

High

1403028

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.537

High

1407367

NKX31
Homeobox protein Nkx-3.1

1

4

Small-scale

0.536

High

134880

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.536

High

686466

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

995298

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.536

High

1062130

SRSF4
Serine/arginine-rich splicing factor 4

1

4

High-throughput

0.536

High

1099565

SRSF6
Serine/arginine-rich splicing factor 6

1

5

High-throughput

0.536

High

1145396

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.536

High

1449084

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1132447

CASP8
Caspase-8

1

1

Small-scale

0.515

High

616010

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

960912

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

1128689

ZN460
Zinc finger protein 460

1

0

High-throughput

0.513

High

1327661

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

1275975

SETX
Probable helicase senataxin

1

2

Small-scale

0.508

High

1288270

LYRIC
Protein LYRIC

1

0

Small-scale

0.504

High

350505

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

2

High-throughput

0.489

High

1449087

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.489

High

227682

SPOP
Speckle-type POZ protein

1

2

Small-scale

0.481

High

964471

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.481

High

1207449

HABP4
Intracellular hyaluronan-binding protein 4

1

2

Small-scale

0.481

High

1334974

SERB1
SERPINE1 mRNA-binding protein 1

1

2

Small-scale

0.481

High

1368494

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

1407903

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.481

High

207665

DHX15
ATP-dependent RNA helicase DHX15

1

5

Small-scale

0.479

High

286087

SF3B1
Splicing factor 3B subunit 1

1

1

Small-scale

0.479

High

445077

S10A9
Protein S100-A9

1

2

Small-scale

0.479

High

485450

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.479

High

487795

PARP1
Poly [ADP-ribose] polymerase 1

1

9

Small-scale

0.479

High

576573

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

Small-scale

0.479

High

655350

SFPQ
Splicing factor, proline- and glutamine-rich

1

3

Small-scale

0.479

High

851677

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

854753

RAGP1
Ran GTPase-activating protein 1

1

1

Small-scale

0.479

High

891327

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

996359

EF1A1
Elongation factor 1-alpha 1

1

5

Small-scale

0.479

High

1005136

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1045817

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1066516

RBBP4
Histone-binding protein RBBP4

1

2

Small-scale

0.479

High

1089029

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1121750

SAFB2
Scaffold attachment factor B2

1

4

Small-scale

0.479

High

1122567

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

Small-scale

0.479

High

1141328

BRD3
Bromodomain-containing protein 3

1

10

High-throughput

0.479

High

1144484

NONO
Non-POU domain-containing octamer-binding protein

1

3

Small-scale

0.479

High

1159022

RBBP7
Histone-binding protein RBBP7

1

4

Small-scale

0.479

High

1347562

SMRC2
SWI/SNF complex subunit SMARCC2

1

1

Small-scale

0.479

High

1363093

DDB2
DNA damage-binding protein 2

1

5

Small-scale

0.479

High

1431127

REN3A
Regulator of nonsense transcripts 3A

1

2

Small-scale

0.479

High

1447310

ANLN
Anillin

1

5

High-throughput

0.479

High

1449082

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

332770

EPM2A
Laforin

1

0

Small-scale

0.460

High

910704

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

1005974

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1346945

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.457

High

387470

APOE
Apolipoprotein E

1

0

High-throughput

0.438

High

1351989

RBCC1
RB1-inducible coiled-coil protein 1

1

13

High-throughput

0.437

High

1276331

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025