HitPredict

Interactor 1: IQG1 (O14188)
Ras GTPase-activating-like protein rng2 (Ring assembly protein 2)
Gene: rng2

Interactor 2: MLR4 (Q09196)
Myosin regulatory light chain cdc4
Gene: cdc4

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.874

Property	Details
Experiments	11942609, 26771498, 20603077, 21422229
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CH~EF-hand_7, EF-hand_7~IQ
Common GO terms	GO:0005737 - cytoplasm GO:0071341 - medial cortical node GO:0110085 - mitotic actomyosin contractile ring GO:1903475 - mitotic actomyosin contractile ring assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1489 Sp			1 141
+	Sp
		144978 IQG1_SCHPO (1-1489): 0: 902: 100.00		CALM_SCHPO (2-140): 5.53e-44: 142: 35.42
+	Hs
		648499 IQGA2_HUMAN (19-1488): 0: 704: 21.48		CALL3_HUMAN (2-140): 3.03e-45: 146: 38.19
+	Hs
		891518 IQGA2_HUMAN (19-1488): 0: 704: 21.48		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Sc
		859593 IQG1_YEAST (3-1488): 4.95e-158: 520: 20.68		MLC1_YEAST (9-139): 6.57e-28: 102: 43.57
+	Hs
		484218 MYO5B_HUMAN (133-1275): 1.28e-96: 346: 9.71		CALM3_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		484206 MYO5C_HUMAN (132-1217): 2.04e-95: 342: 9.79		CALM3_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Dm
		51921 A1Z6Z9_DROME (127-1228): 3.34e-89: 323: 10.67		CALM_DROME (2-140): 2.2e-47: 151: 38.19
+	Dm
		51920 A1Z6Z9_DROME (127-1228): 3.34e-89: 323: 10.67		MLC2_DROME (2-140): 7.73e-45: 145: 34.75
+	Hs
		483957 SYGP1_HUMAN (792-1224): 1.67e-62: 237: 12.93		CALM1_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		891587 SYGP1_HUMAN (792-1224): 1.67e-62: 237: 12.93		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Hs
		57913 A2RRC9_HUMAN (29-399): 2.93e-43: 175: 23.56		B4DJ51_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		483946 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		CALM1_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		484020 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		CALM2_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		484161 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		CALM3_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		538684 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		MYL6B_HUMAN (3-140): 2.39e-42: 140: 38.89
+	Hs
		891555 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		MYL6_HUMAN (2-140): 5.07e-43: 140: 37.24
+	Hs
		483913 IQGA1_HUMAN (19-367): 2.99e-38: 159: 23.35		CALM1_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		483984 IQGA1_HUMAN (19-367): 2.99e-38: 159: 23.35		CALM2_HUMAN (2-140): 7.28e-48: 152: 39.58
+	Hs
		521684 IQGA3_HUMAN (29-399): 4.51e-43: 174: 23.56		MYL4_HUMAN (8-140): 1.08e-25: 97.8: 41.14
+	Hs
		409454 IQGA1_HUMAN (19-367): 2.99e-38: 159: 23.35		MYL1_HUMAN (8-140): 1.9e-25: 97.1: 38.13