HitPredict

Interactor 1: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 795 Hs			1 1620
+	Hs
		1270553 MARK2_HUMAN (2-795): 0: 664: 63.51		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		692157 MARK3_HUMAN (1-795): 0: 654: 63.32		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		463994 MARK2_HUMAN (2-795): 0: 664: 63.51		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		691999 MARK3_HUMAN (1-795): 0: 654: 63.32		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		439764 MARK2_HUMAN (2-795): 0: 664: 63.51		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Hs
		412142 MARK2_HUMAN (2-795): 0: 664: 63.51		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		692072 MARK3_HUMAN (1-795): 0: 654: 63.32		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		411397 MARK3_HUMAN (1-795): 0: 654: 63.32		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541351 MARK3_HUMAN (1-795): 0: 654: 63.32		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		439718 AAPK1_HUMAN (34-579): 2.98e-142: 432: 27.92		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Rn
		1066602 AAPK2_RAT (46-572): 6.9e-142: 431: 30.45		T2CB11_RAT (973-1484): 1.47e-112: 392: 32.38
+	Rn
		580454 AAPK1_RAT (34-579): 5.92e-142: 431: 28.10		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Rn
		580482 AAPK2_RAT (46-572): 6.9e-142: 431: 30.45		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Rn
		930662 AAPK1_RAT (34-579): 5.92e-142: 431: 28.10		T2CB11_RAT (973-1484): 1.47e-112: 392: 32.38
+	Hs
		439689 AAPK2_HUMAN (46-572): 3.97e-141: 429: 30.45		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Hs
		411846 AAPK1_HUMAN (34-579): 2.98e-142: 432: 27.92		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1095381 AAPK1_HUMAN (34-579): 2.98e-142: 432: 27.92		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03