HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.80	0.731

Property	Details
Experiments	10882725, 12027890
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 508
+	Mm
		193372 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69
+	Hs
		147382 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		GHR_HUMAN (6-482): 1.38e-87: 283: 15.10
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03
+	Hs
		147383 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52
+	Hs
		411991 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92
+	Hs
		412028 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL3RA_HUMAN (37-316): 4.98e-41: 153: 20.00
+	Hs
		412037 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA8_HUMAN (2-369): 1.81e-38: 152: 13.80
+	Hs
		256850 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		IL4RA_HUMAN (48-496): 2.05e-38: 151: 14.78
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (19-483): 1.95e-33: 137: 13.92
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (40-256): 3.49e-32: 133: 17.27
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (49-259): 5.61e-29: 123: 12.50
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (64-483): 1.74e-23: 106: 12.72
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (64-483): 1.74e-23: 106: 12.72
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (8-269): 5.2e-13: 73.9: 16.31
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (6-234): 1.46e-11: 69.2: 17.24