HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	28883622, 12052866
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1257
+	Hs
		151689 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151692 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		146566 SOCS2_HUMAN (344-535): 7.98e-46: 161: 30.81		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151857 P55G_HUMAN (380-505): 3.47e-19: 92.1: 26.19		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		129141 P85B_HUMAN (380-491): 1.89e-14: 78.2: 27.68		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151716 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Dm
		186292 O18683_DROME (355-519): 3.69e-34: 137: 23.98		IRS1_DROME (83-354): 1.31e-71: 261: 30.00
+	Mm
		639440 LYN_MOUSE (292-495): 2.8e-46: 171: 15.28		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		208999 NCK2_HUMAN (182-466): 4.45e-53: 186: 17.04		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		412057 FYN_HUMAN (324-506): 2.87e-51: 185: 15.63		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		146670 SOCS7_HUMAN (370-535): 6e-45: 168: 53.57		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		181903 SOCS1_HUMAN (379-535): 5.8e-42: 151: 26.75		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		181808 SOCS1_HUMAN (379-535): 5.8e-42: 151: 26.75		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		147455 SOCS3_HUMAN (372-533): 7.64e-38: 140: 26.56		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		147396 SOCS3_HUMAN (372-533): 7.64e-38: 140: 26.56		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		1267462 P55G_HUMAN (380-505): 3.47e-19: 92.1: 26.19		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Mm
		643075 P85A_MOUSE (384-496): 1.31e-12: 72.4: 23.89		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		724554 P55G_HUMAN (380-505): 3.47e-19: 92.1: 26.19		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		129219 P85B_HUMAN (380-491): 1.89e-14: 78.2: 27.68		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Mm
		643063 P85A_MOUSE (384-496): 1.31e-12: 72.4: 23.89		IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51