HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.885

The method score is based on:

Property Details
Experiments 25814554, 26186194, 33961781, unassigned1126
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~SH2, SH2~SOCS_box
Common GO terms GO:0005829 - cytosol
GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0046854 - phosphatidylinositol phosphate biosynthetic process
GO:0046935 - 1-phosphatidylinositol-3-kinase regulator activity
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 535
Hs

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Last updated: 15 Jul 2024