HitPredict

Interactor 1: DC1I1 (O14576)
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)
Gene: DYNC1I1

Interactor 2: DLRB1 (Q9NP97)
Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)
Gene: DYNLRB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	16189514, 28718761, 33961781
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003777 - microtubule motor activity GO:0005737 - cytoplasm GO:0005868 - cytoplasmic dynein complex GO:0005874 - microtubule
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 96
+	Hs
		1033341 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DLRB1_HUMAN (1-96): 3.9e-43: 137: 100.00
+	Dm
		1096833 DYIN_DROME (6-635): 2.04e-103: 330: 46.46		Q7KMS3_DROME (3-96): 5.78e-41: 131: 74.47
+	Ce
		219877 O45087_CAEEL (7-636): 9.6e-93: 301: 34.20		Q22752_CAEEL (1-93): 6.46e-34: 113: 49.46
+	Hs
		1257077 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DLRB2_HUMAN (1-96): 3.82e-43: 137: 77.08
+	Hs
		1261765 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DLRB1_HUMAN (1-96): 3.9e-43: 137: 100.00
+	Hs
		1257079 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DLRB2_HUMAN (1-96): 3.82e-43: 137: 77.08
+	Hs
		1290458 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DLRB1_HUMAN (1-96): 3.9e-43: 137: 100.00
+	Hs
		793016 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DLRB2_HUMAN (1-96): 3.82e-43: 137: 77.08