HitPredict

Interactor 1: CTRO (O14578)
Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)
Gene: CIT

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PH, PH~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2027 Hs			1 1025
+	Hs
		148126 CTRO_HUMAN (1-2027): 0: 1212: 100.00		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		149443 CTRO_HUMAN (1-2027): 0: 1212: 100.00		PKHA6_HUMAN (356-581): 1.69e-31: 135: 24.49
+	Hs
		148460 CTRO_HUMAN (1-2027): 0: 1212: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Rn
		92843 CTRO_RAT (1-2027): 0: 1136: 93.58		ROCK2_RAT (502-969): 4.64e-41: 166: 18.71
+	Hs
		148461 CTRO_HUMAN (1-2027): 0: 1212: 100.00		MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18
+	Hs
		148466 CTRO_HUMAN (1-2027): 0: 1212: 100.00		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		148841 CTRO_HUMAN (1-2027): 0: 1212: 100.00		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		148991 CTRO_HUMAN (1-2027): 0: 1212: 100.00		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		116964 SGK1_HUMAN (59-407): 8.42e-121: 390: 31.37		MYH1_HUMAN (122-873): 2.75e-15: 83.2: 8.13
+	Hs
		117013 SGK1_HUMAN (59-407): 8.42e-121: 390: 31.37		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		1153402 LATS2_HUMAN (103-400): 4.87e-58: 222: 39.26		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		1334846 LATS2_HUMAN (103-400): 4.87e-58: 222: 39.26		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		149340 LATS2_HUMAN (103-400): 4.87e-58: 222: 39.26		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		725079 ST38L_HUMAN (74-430): 6.61e-69: 242: 35.79		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Bt
		1100183 ROCK2_BOVIN (849-1552): 9.07e-35: 148: 8.35		ROCK2_BOVIN (492-990): 3.23e-14: 79.7: 13.69
+	Hs
		724810 ROCK1_HUMAN (1051-1566): 8.4e-21: 102: 10.08		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		254476 ROCK1_HUMAN (1051-1566): 8.4e-21: 102: 10.08		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		623875 KPCL_HUMAN (1355-1514): 4.34e-12: 73.3: 16.36		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96