HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 1130
+	Hs
		150803 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		876514 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Hs
		325825 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		325820 INADL_HUMAN (249-359): 2.73e-12: 72.6: 27.03		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		325859 MAGI1_HUMAN (118-687): 3.03e-12: 72.2: 11.70		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		1344984 GRIP1_HUMAN (163-625): 8.94e-21: 99: 12.70		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Hs
		1256906 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Hs
		1246440 INADL_HUMAN (249-359): 2.73e-12: 72.6: 27.03		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Hs
		1300675 MAGI1_HUMAN (118-687): 3.03e-12: 72.2: 11.70		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Mm
		933108 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		KAPCB_MOUSE (661-1056): 2.81e-133: 410: 32.25
+	Hs
		568771 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Mm
		933109 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		KAPCB_MOUSE (661-1056): 2.81e-133: 410: 32.25
+	Ce
		88187 D3YT29_CAEEL (89-321): 2.03e-14: 78.9: 19.17		WARTS_CAEEL (397-1088): 1.32e-154: 486: 35.43
+	Hs
		876412 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		MRCKA_HUMAN (694-1047): 2.92e-66: 248: 39.06
+	Hs
		876374 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94
+	Hs
		568742 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Mm
		936586 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		ROCK2_MOUSE (694-1046): 5.43e-62: 234: 38.27
+	Mm
		936587 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		ROCK2_MOUSE (694-1046): 5.43e-62: 234: 38.27
+	Hs
		1200039 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		MRCKB_HUMAN (695-1047): 8.47e-63: 236: 38.06
+	Hs
		1137888 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		MRCKA_HUMAN (694-1047): 2.92e-66: 248: 39.06