HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20224554, 11425858
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008013 - beta-catenin binding GO:0016328 - lateral plasma membrane GO:0019901 - protein kinase binding GO:1990909 - Wnt signalosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 2843
+	Hs
		626082 DVLP1_HUMAN (1-695): 0: 532: 92.81		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		150855 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Mm
		1141494 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		APC_MOUSE (1-2843): 0: 1220: 89.82
+	Hs
		626083 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		626115 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Rn
		677772 DLG4_RAT (104-626): 1.68e-56: 207: 17.60		APC_RAT (1-2843): 0: 1222: 89.60
+	Mm
		1142526 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		APC_MOUSE (1-2843): 0: 1220: 89.82
+	Ce
		1094130 MIG5_CAEEL (2-501): 2.28e-67: 235: 27.31		APR1_CAEEL (274-1464): 5.62e-115: 399: 16.91
+	Hs
		151109 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		876457 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		297818 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		K0754_HUMAN (1032-1505): 1.35e-11: 73.3: 13.47
+	Mm
		1143541 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		MAP1A_MOUSE (738-2466): 8.19e-18: 93.6: 8.21
+	Mm
		1143421 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		ANK2_MOUSE (1056-2841): 1.1e-15: 86.5: 9.74
+	Hs
		942322 DLG4_HUMAN (104-626): 3.61e-56: 205: 17.42		MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68
+	Hs
		944673 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68
+	Rn
		677763 DLG4_RAT (104-626): 1.68e-56: 207: 17.60		MAP1A_RAT (823-2474): 2.27e-13: 78.8: 8.11
+	Rn
		713905 DLG1_RAT (23-637): 2.87e-55: 205: 15.44		MAP1A_RAT (823-2474): 2.27e-13: 78.8: 8.11
+	Mm
		1164092 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		MAP1A_MOUSE (738-2466): 8.19e-18: 93.6: 8.21
+	Mm
		292195 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		BSN_MOUSE (1103-2836): 4.7e-16: 87.8: 7.21
+	Mm
		1163989 NEB2_MOUSE (75-423): 2.88e-48: 184: 15.62		ANK2_MOUSE (1056-2841): 1.1e-15: 86.5: 9.74