HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: MRP2 (Q92887)
ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
Gene: ABCC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	25163515, 12615054
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016324 - apical plasma membrane GO:0150104 - transport across blood-brain barrier
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 358 Hs			1 1545
+	Rn
		1144126 NHRF1_RAT (1-358): 2.87e-79: 248: 86.35		MRP2_RAT (2-1545): 0: 1126: 76.88
+	Hs
		1132912 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		MRP2_HUMAN (1-1545): 0: 1140: 100.00
+	Hs
		1200079 NHRF4_HUMAN (93-235): 8.62e-12: 68.1: 22.22		MRP2_HUMAN (1-1545): 0: 1140: 100.00
+	Hs
		153846 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179358 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179356 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179363 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		67899 PDZ1P_HUMAN (142-346): 3.81e-15: 77.8: 19.02		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179374 SNX27_HUMAN (12-91): 4.35e-09: 59.7: 37.63		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31