HitPredict

Interactor 1: TERT (O14746)
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
Gene: TERT

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

The method score is based on:

Property	Details
Experiments	18775701, 28205554, 15843522
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010629 - negative regulation of gene expression and 5 others more... GO:0042803 - protein homodimerization activity GO:0046326 - positive regulation of glucose import GO:0051000 - positive regulation of nitric-oxide synthase activity GO:1900087 - positive regulation of G1/S transition of mitotic cell cycle GO:2001240 - negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	1132
Hs

1	480

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024