HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: SLAF1 (Q13291)
Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
Gene: SLAMF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.623

Property	Details
Experiments	11689425, 22974441, 10549287
Identification Methods	unspecified method, two hybrid, pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 335
+	Hs
		412176 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SLAF1_HUMAN (1-335): 3.45e-80: 249: 100.00
+	Hs
		243137 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF1_HUMAN (1-335): 3.45e-80: 249: 100.00
+	Mm
		1115123 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77
+	Mm
		1061798 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77
+	Mm
		192617 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77
+	Mm
		763408 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SLAF1_MOUSE (1-335): 1.89e-69: 222: 59.77
+	Hs
		155857 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF7_HUMAN (5-334): 1e-59: 196: 19.46
+	Mm
		192616 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF7_MOUSE (10-334): 4.49e-58: 192: 17.77
+	Hs
		243158 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF7_HUMAN (5-334): 1e-59: 196: 19.46
+	Hs
		155858 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF5_HUMAN (15-334): 6.3e-54: 181: 21.21
+	Hs
		176495 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		155856 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Mm
		991971 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		CD244_MOUSE (10-331): 6.3e-48: 167: 21.45
+	Hs
		412347 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		243155 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		411939 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD2_HUMAN (14-323): 1.49e-47: 165: 18.79
+	Hs
		243157 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		LY9_HUMAN (10-246): 1.54e-43: 160: 22.54
+	Hs
		155852 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04
+	Hs
		243153 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04
+	Hs
		412008 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29