HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	24642916, 23346089
Identification Methods	surface plasmon resonance, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 370
+	Hs
		176495 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		412347 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		243155 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Mm
		991971 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		CD244_MOUSE (1-370): 3.04e-82: 257: 46.67
+	Hs
		155858 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Mm
		1115123 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Mm
		1061798 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Mm
		192617 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		243161 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Mm
		763408 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		155852 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		243153 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Mm
		192616 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF7_MOUSE (6-345): 5.16e-50: 172: 16.05
+	Hs
		155857 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Hs
		243158 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Hs
		155840 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		243157 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		412176 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		243137 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		411939 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24