HitPredict

Interactor 1: RASM (O14807)
Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
Gene: MRAS

Interactor 2: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11524421
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0030742 - GTP-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 208 Hs			1 1601
+	Hs
		919653 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF6_HUMAN (1-1601): 0: 1379: 100.00
+	Hs
		992491 RIT2_HUMAN (14-189): 2.78e-55: 176: 50.84		SOS1_HUMAN (650-1398): 1.89e-107: 375: 14.38
+	Hs
		156094 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Dm
		442976 RAP1_DROME (14-175): 2.88e-57: 180: 54.32		Q9VMF3_DROME (737-1277): 2.7e-89: 323: 36.68
+	Hs
		905457 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		897964 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		919681 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		905420 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		919625 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF1_HUMAN (587-1112): 1.46e-76: 279: 17.36
+	Hs
		897883 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		919618 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		1021728 RIT2_HUMAN (14-189): 2.78e-55: 176: 50.84		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Sc
		350755 RAS1_YEAST (14-176): 1.24e-54: 177: 58.90		CDC25_YEAST (807-1058): 4.7e-64: 243: 25.29
+	Hs
		156101 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		RPGF5_HUMAN (413-508): 3.9e-18: 92.1: 22.12
+	Hs
		313169 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RPGF3_HUMAN (6-145): 1.03e-39: 162: 24.50
+	Hs
		313171 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF3_HUMAN (6-145): 1.03e-39: 162: 24.50
+	Ce
		1089983 RAP1_CAEEL (11-208): 2.42e-85: 251: 46.47		Q19770_CAEEL (854-1080): 7.07e-13: 75.5: 26.41
+	Hs
		919657 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF5_HUMAN (413-508): 3.9e-18: 92.1: 22.12
+	Hs
		919656 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF4_HUMAN (255-376): 1.78e-12: 74.7: 22.48
+	Hs
		919687 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF2_HUMAN (9-152): 6.41e-11: 69.7: 17.65