HitPredict

Interactor 1: IFIT3 (O14879)
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
Gene: IFIT3

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21813773
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0051607 - defense response to virus GO:0140374 - antiviral innate immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 540
+	Hs
		456286 IFIT1_HUMAN (1-453): 1.03e-86: 276: 42.74		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		175005 OGT1_HUMAN (8-242): 6e-34: 138: 17.45		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Mm
		1186484 OGT1_MOUSE (8-218): 6.7e-34: 138: 18.96		HUWE1_MOUSE (108-539): 1.87e-18: 91.8: 13.89
+	Hs
		174891 OGT1_HUMAN (8-242): 6e-34: 138: 17.45		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		175053 OGT1_HUMAN (8-242): 6e-34: 138: 17.45		KMT2C_HUMAN (57-528): 6.72e-09: 61: 10.42
+	Hs
		183137 KDM6A_HUMAN (38-401): 7.2e-34: 138: 10.24		KMT2C_HUMAN (57-528): 6.72e-09: 61: 10.42
+	Hs
		150104 UTY_HUMAN (38-372): 8.38e-33: 134: 11.03		KMT2C_HUMAN (57-528): 6.72e-09: 61: 10.42
+	Hs
		672833 CDC27_HUMAN (86-489): 4.89e-27: 117: 11.06		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48