HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: TRI40 (Q6P9F5)
E3 ubiquitin ligase TRIM40 (EC 2.3.2.27) (Probable E3 NEDD8-protein ligase) (RING finger protein 35)
Gene: TRIM40

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21474709
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008385 - IkappaB kinase complex GO:0045087 - innate immune response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 258
+	Hs
		158392 IKKB_HUMAN (1-756): 0: 662: 100.00		RO52_HUMAN (5-258): 1.52e-52: 178: 21.86
+	Hs
		158386 IKKB_HUMAN (1-756): 0: 662: 100.00		TRI27_HUMAN (2-253): 9.72e-45: 159: 20.21
+	Hs
		167580 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		TRI22_HUMAN (2-258): 1.4e-53: 182: 20.78
+	Hs
		167459 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		TRI27_HUMAN (2-253): 9.72e-45: 159: 20.21
+	Hs
		167566 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		TRI40_HUMAN (1-258): 1.19e-44: 152: 100.00
+	Hs
		1050264 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		TRIM6_HUMAN (3-258): 1.1e-55: 187: 22.97
+	Hs
		1050263 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		TRIM7_HUMAN (9-253): 8.54e-50: 172: 20.62
+	Hs
		584875 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		RO52_HUMAN (5-258): 1.52e-52: 178: 21.86
+	Hs
		536827 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		TRI27_HUMAN (2-253): 9.72e-45: 159: 20.21
+	Hs
		585090 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		RO52_HUMAN (5-258): 1.52e-52: 178: 21.86
+	Hs
		1019379 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		TRI26_HUMAN (4-242): 4.42e-50: 173: 23.53
+	Hs
		1318703 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		TRIM7_HUMAN (9-253): 8.54e-50: 172: 20.62
+	Hs
		537119 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		TRI27_HUMAN (2-253): 9.72e-45: 159: 20.21
+	Hs
		1354523 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		TRI10_HUMAN (4-253): 1.46e-43: 155: 22.42
+	Mm
		1143608 TBK1_MOUSE (15-370): 3.38e-94: 311: 25.95		TRI27_MOUSE (2-253): 7.12e-45: 159: 20.21
+	Hs
		262235 ULK1_HUMAN (9-222): 5.77e-30: 129: 34.98		RO52_HUMAN (5-258): 1.52e-52: 178: 21.86
+	Hs
		262230 ULK1_HUMAN (9-222): 5.77e-30: 129: 34.98		TRI27_HUMAN (2-253): 9.72e-45: 159: 20.21
+	Mm
		250797 ULK1_MOUSE (10-222): 7.24e-29: 125: 34.23		TRI27_MOUSE (2-253): 7.12e-45: 159: 20.21