HitPredict

Interactor 1: RGS13 (O14921)
Regulator of G-protein signaling 13 (RGS13)
Gene: RGS13

Interactor 2: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12193720
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 159 Hs			1 355
+	Hs
		391357 RGS3_HUMAN (12-159): 2.42e-62: 208: 40.54		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		283156 RGS20_HUMAN (18-157): 7.48e-62: 196: 42.86		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		444692 RGS3_HUMAN (12-159): 2.42e-62: 208: 40.54		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		283183 RGS20_HUMAN (18-157): 7.48e-62: 196: 42.86		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		391356 RGS19_HUMAN (9-158): 5.55e-59: 184: 40.00		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		926723 RGS17_HUMAN (2-158): 2.68e-60: 187: 35.67		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		283160 RGS20_HUMAN (18-157): 7.48e-62: 196: 42.86		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		277782 RGS9_HUMAN (5-155): 2.26e-58: 194: 30.72		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		444693 RGS7_HUMAN (5-156): 2.31e-57: 187: 28.95		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		444806 RGS17_HUMAN (2-158): 2.68e-60: 187: 35.67		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		444691 RGS19_HUMAN (9-158): 5.55e-59: 184: 40.00		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		450988 RGS19_HUMAN (9-158): 5.55e-59: 184: 40.00		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		670435 RGS3_HUMAN (12-159): 2.42e-62: 208: 40.54		GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42
+	Hs
		158584 RGS13_HUMAN (1-159): 3.38e-65: 197: 100.00		GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42
+	Bt
		221230 RGS9_BOVIN (5-155): 6.94e-58: 189: 30.07		GNAT1_BOVIN (1-355): 6.59e-165: 465: 65.92
+	Dm
		558483 RGS_DROME (16-159): 2.1e-54: 185: 29.03		GNAO_DROME (1-355): 9.4e-166: 468: 67.89
+	Hs
		834946 RGS7_HUMAN (5-156): 2.31e-57: 187: 28.95		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		283162 RGS20_HUMAN (18-157): 7.48e-62: 196: 42.86		GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38
+	Dm
		592744 RGS_DROME (16-159): 2.1e-54: 185: 29.03		GNAI_DROME (1-355): 1.12e-163: 463: 76.40
+	Hs
		580410 RGS7_HUMAN (5-156): 2.31e-57: 187: 28.95		GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38