HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head
Common GO terms	GO:0005737 - cytoplasm GO:0016460 - myosin II complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 2054
+	Hs
		580672 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MY18A_HUMAN (1-2054): 0: 1279: 100.00
+	Hs
		159549 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		624341 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		580614 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Dm
		773034 SQH_DROME (1-172): 2.29e-61: 189: 81.03		MYSN_DROME (1218-1932): 2.19e-38: 160: 23.06
+	Hs
		501101 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYH1_HUMAN (959-1794): 5.17e-37: 156: 9.50
+	Hs
		159551 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		159550 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		580616 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		624342 MYL9_HUMAN (1-172): 2.61e-66: 201: 93.02		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-172): 7.34e-67: 203: 97.67		MYH10_MOUSE (1697-2040): 4.43e-17: 90.6: 14.78
+	Hs
		580615 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		159640 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYO5A_HUMAN (1789-2053): 7.86e-13: 76.7: 12.84
+	Hs
		159595 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		580665 ML12A_HUMAN (15-172): 2.3e-65: 199: 99.37		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08
+	Hs
		159635 ML12B_HUMAN (1-172): 1.42e-67: 204: 100.00		MYH15_HUMAN (1248-1834): 8.79e-09: 63.2: 18.86
+	Hs
		501117 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYO5B_HUMAN (1603-2051): 4.65e-14: 80.6: 9.19
+	Hs
		501118 MLRV_HUMAN (9-166): 1.98e-54: 171: 57.23		MYO5A_HUMAN (1789-2053): 7.86e-13: 76.7: 12.84
+	Hs
		648467 CALL3_HUMAN (32-93): 8.36e-11: 58.6: 25.76		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Dm
		404219 MLR_DROME (13-163): 1.86e-29: 109: 42.21		MYSA_DROME (1659-2054): 1.99e-22: 108: 12.50